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Design, synthesis and cytotoxicity of novel chalcone analogs derived from 1-cyclohexylpyrrolidin-2-one and 2,3-dihydrobenzo[f]chromen-1-one.
Arch Pharm (Weinheim). 2012 May;345(5):341-8. doi: 10.1002/ardp.201100265. Epub 2011 Nov 11.
Arch Pharm (Weinheim). 2012.
PMID: 22076705
Synthesis and DNA binding properties of 1-(3-aminopropyl)-imidazole-containing triamide f-Im*PyIm: a novel diamino polyamide designed to target 5'-ACGCGT-3'.
Satam V, Babu B, Porte A, Savagian M, Lee M, Smeltzer T, Liu Y, Ramos J, Wilson WD, Lin S, Kiakos K, Hartley JA, Lee M.
Satam V, et al. Among authors: savagian m.
Bioorg Med Chem Lett. 2012 Sep 15;22(18):5898-902. doi: 10.1016/j.bmcl.2012.07.071. Epub 2012 Jul 27.
Bioorg Med Chem Lett. 2012.
PMID: 22892118
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Novel diamino imidazole and pyrrole-containing polyamides: Synthesis and DNA binding studies of mono- and diamino-phenyl-ImPy*Im polyamides designed to target 5'-ACGCGT-3'.
Satam V, Babu B, Chavda S, Savagian M, Sjoholm R, Tzou S, Ramos J, Liu Y, Kiakos K, Lin S, David Wilson W, Hartley JA, Lee M.
Satam V, et al. Among authors: savagian m.
Bioorg Med Chem. 2012 Jan 15;20(2):693-701. doi: 10.1016/j.bmc.2011.12.010. Epub 2011 Dec 14.
Bioorg Med Chem. 2012.
PMID: 22222156
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AzaHx, a novel fluorescent, DNA minor groove and G·C recognition element: Synthesis and DNA binding properties of a p-anisyl-4-aza-benzimidazole-pyrrole-imidazole (azaHx-PI) polyamide.
Satam V, Babu B, Patil P, Brien KA, Olson K, Savagian M, Lee M, Mepham A, Jobe LB, Bingham JP, Pett L, Wang S, Ferrara M, Bruce CD, Wilson WD, Lee M, Hartley JA, Kiakos K.
Satam V, et al. Among authors: savagian m.
Bioorg Med Chem Lett. 2015 Sep 1;25(17):3681-5. doi: 10.1016/j.bmcl.2015.06.055. Epub 2015 Jun 19.
Bioorg Med Chem Lett. 2015.
PMID: 26122210
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Hx-amides: DNA sequence recognition by the fluorescent Hx (p-anisylbenzimidazole)•pyrrole and Hx•imidazole pairings.
Satam V, Patil P, Babu B, Gregory M, Bowerman M, Savagian M, Lee M, Tzou S, Olson K, Liu Y, Ramos J, Wilson WD, Bingham JP, Kiakos K, Hartley JA, Lee M.
Satam V, et al. Among authors: savagian m.
Bioorg Med Chem Lett. 2013 Mar 15;23(6):1699-702. doi: 10.1016/j.bmcl.2013.01.075. Epub 2013 Jan 25.
Bioorg Med Chem Lett. 2013.
PMID: 23395654
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Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide.
Pett L, Kiakos K, Satam V, Patil P, Laughlin-Toth S, Gregory M, Bowerman M, Olson K, Savagian M, Lee M, Lee M, Wilson WD, Hochhauser D, Hartley JA.
Pett L, et al. Among authors: savagian m.
Biochim Biophys Acta Gene Regul Mech. 2017 May;1860(5):617-629. doi: 10.1016/j.bbagrm.2016.10.005. Epub 2016 Oct 24.
Biochim Biophys Acta Gene Regul Mech. 2017.
PMID: 27750031
Free PMC article.
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Affinity and kinetic modulation of polyamide-DNA interactions by N-modification of the heterocycles.
Ramos JP, Babu B, Chavda S, Liu Y, Plaunt A, Ferguson A, Savagian M, Lee M, Tzou S, Lin S, Kiakos K, Wang S, Lee M, Hartley JA, Wilson WD.
Ramos JP, et al. Among authors: savagian m.
Biopolymers. 2013 Aug;99(8):497-507. doi: 10.1002/bip.22205.
Biopolymers. 2013.
PMID: 23712486
Free PMC article.
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