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Ceragenins exhibit antiviral activity against SARS-CoV-2 by increasing the expression and release of type I interferons upon activation of the host's immune response.
Suprewicz Ł, Szczepański A, Lenart M, Piktel E, Fiedoruk K, Barreto-Duran E, Kula-Pacurar A, Savage PB, Milewska A, Bucki R, Pyrć K. Suprewicz Ł, et al. Among authors: savage pb. Antiviral Res. 2023 Sep;217:105676. doi: 10.1016/j.antiviral.2023.105676. Epub 2023 Jul 20. Antiviral Res. 2023. PMID: 37481038
Ceragenins exhibit bactericidal properties that are independent of the ionic strength in the environment mimicking cystic fibrosis sputum.
Skłodowski K, Suprewicz Ł, Chmielewska-Deptuła SJ, Kaliniak S, Okła S, Zakrzewska M, Minarowski Ł, Mróz R, Daniluk T, Savage PB, Fiedoruk K, Bucki R. Skłodowski K, et al. Among authors: savage pb. Front Microbiol. 2023 Nov 17;14:1290952. doi: 10.3389/fmicb.2023.1290952. eCollection 2023. Front Microbiol. 2023. PMID: 38045035 Free PMC article.
Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms.
Mitchell G, Silvis MR, Talkington KC, Budzik JM, Dodd CE, Paluba JM, Oki EA, Trotta KL, Licht DJ, Jimenez-Morales D, Chou S, Savage PB, Gross CA, Marletta MA, Cox JS. Mitchell G, et al. Among authors: savage pb. mBio. 2022 Feb 22;13(1):e0272621. doi: 10.1128/mbio.02726-21. Epub 2022 Jan 25. mBio. 2022. PMID: 35073755 Free PMC article.
Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature.
Costanzo A, Clarke D, Holt M, Sharma S, Nagy K, Tan X, Kain L, Abe B, Luce S, Boitard C, Wyseure T, Mosnier LO, Su AI, Grimes C, Finn MG, Savage PB, Gottschalk M, Pettus J, Teyton L. Costanzo A, et al. Among authors: savage pb. J Immunol. 2024 Apr 1;212(7):1094-1104. doi: 10.4049/jimmunol.2300769. J Immunol. 2024. PMID: 38426888 Free PMC article.
Preventing osteolytic lesions and osteomyelitis in multiple myeloma.
Dao A, McDonald MM, Savage PB, Little DG, Schindeler A. Dao A, et al. Among authors: savage pb. J Bone Oncol. 2022 Oct 28;37:100460. doi: 10.1016/j.jbo.2022.100460. eCollection 2022 Dec. J Bone Oncol. 2022. PMID: 36388641 Free PMC article. Review.
203 results