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Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability.
Savage KI, Gorski JJ, Barros EM, Irwin GW, Manti L, Powell AJ, Pellagatti A, Lukashchuk N, McCance DJ, McCluggage WG, Schettino G, Salto-Tellez M, Boultwood J, Richard DJ, McDade SS, Harkin DP. Savage KI, et al. Mol Cell. 2014 May 8;54(3):445-59. doi: 10.1016/j.molcel.2014.03.021. Epub 2014 Apr 17. Mol Cell. 2014. PMID: 24746700 Free PMC article.
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.
Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK. Richard DJ, et al. Nature. 2008 May 29;453(7195):677-81. doi: 10.1038/nature06883. Epub 2008 Apr 30. Nature. 2008. PMID: 18449195
Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin.
Bolderson E, Savage KI, Mahen R, Pisupati V, Graham ME, Richard DJ, Robinson PJ, Venkitaraman AR, Khanna KK. Bolderson E, et al. Among authors: savage ki. J Biol Chem. 2012 Aug 10;287(33):28122-31. doi: 10.1074/jbc.M112.368381. Epub 2012 Jun 18. J Biol Chem. 2012. PMID: 22715096 Free PMC article.
NF-κB is a critical mediator of BRCA1-induced chemoresistance.
Harte MT, Gorski JJ, Savage KI, Purcell JW, Barros EM, Burn PM, McFarlane C, Mullan PB, Kennedy RD, Perkins ND, Harkin DP. Harte MT, et al. Among authors: savage ki. Oncogene. 2014 Feb 6;33(6):713-723. doi: 10.1038/onc.2013.10. Epub 2013 Feb 25. Oncogene. 2014. PMID: 23435429 Free PMC article.
Antiproton induced DNA damage: proton like in flight, carbon-ion like near rest.
Kavanagh JN, Currell FJ, Timson DJ, Savage KI, Richard DJ, McMahon SJ, Hartley O, Cirrone GA, Romano F, Prise KM, Bassler N, Holzscheiter MH, Schettino G. Kavanagh JN, et al. Among authors: savage ki. Sci Rep. 2013;3:1770. doi: 10.1038/srep01770. Sci Rep. 2013. PMID: 23640660 Free PMC article.
42 results