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Page 1
A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins.
Pérez-Perarnau A, Preciado S, Palmeri CM, Moncunill-Massaguer C, Iglesias-Serret D, González-Gironès DM, Miguel M, Karasawa S, Sakamoto S, Cosialls AM, Rubio-Patiño C, Saura-Esteller J, Ramón R, Caja L, Fabregat I, Pons G, Handa H, Albericio F, Gil J, Lavilla R. Pérez-Perarnau A, et al. Angew Chem Int Ed Engl. 2014 Sep 15;53(38):10150-4. doi: 10.1002/anie.201405758. Epub 2014 Sep 5. Angew Chem Int Ed Engl. 2014. PMID: 25196378
A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation.
Moncunill-Massaguer C, Saura-Esteller J, Pérez-Perarnau A, Palmeri CM, Núñez-Vázquez S, Cosialls AM, González-Gironès DM, Pomares H, Korwitz A, Preciado S, Albericio F, Lavilla R, Pons G, Langer T, Iglesias-Serret D, Gil J. Moncunill-Massaguer C, et al. Oncotarget. 2015 Dec 8;6(39):41750-65. doi: 10.18632/oncotarget.6154. Oncotarget. 2015. PMID: 26497683 Free PMC article.
Targeting prohibitins induces apoptosis in acute myeloid leukemia cells.
Pomares H, Palmeri CM, Iglesias-Serret D, Moncunill-Massaguer C, Saura-Esteller J, Núñez-Vázquez S, Gamundi E, Arnan M, Preciado S, Albericio F, Lavilla R, Pons G, González-Barca EM, Cosialls AM, Gil J. Pomares H, et al. Among authors: saura esteller j. Oncotarget. 2016 Oct 4;7(40):64987-65000. doi: 10.18632/oncotarget.11333. Oncotarget. 2016. PMID: 27542247 Free PMC article.
The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax.
Cosialls AM, Pomares H, Iglesias-Serret D, Saura-Esteller J, Núñez-Vázquez S, González-Gironès DM, de la Banda E, Preciado S, Albericio F, Lavilla R, Pons G, González-Barca EM, Gil J. Cosialls AM, et al. Among authors: saura esteller j. Haematologica. 2017 Sep;102(9):1587-1593. doi: 10.3324/haematol.2016.162958. Epub 2017 Jun 15. Haematologica. 2017. PMID: 28619845 Free PMC article.
NOXA upregulation by the prohibitin-binding compound fluorizoline is transcriptionally regulated by integrated stress response-induced ATF3 and ATF4.
Núñez-Vázquez S, Sánchez-Vera I, Saura-Esteller J, Cosialls AM, Noisier AFM, Albericio F, Lavilla R, Pons G, Iglesias-Serret D, Gil J. Núñez-Vázquez S, et al. Among authors: saura esteller j. FEBS J. 2021 Feb;288(4):1271-1285. doi: 10.1111/febs.15480. Epub 2020 Jul 26. FEBS J. 2021. PMID: 32648994 Free article.
The BCL-2 family members NOXA and BIM mediate fluorizoline-induced apoptosis in multiple myeloma cells.
Cosialls AM, Sánchez-Vera I, Pomares H, Perramon-Andújar J, Sanchez-Esteban S, Palmeri CM, Iglesias-Serret D, Saura-Esteller J, Núñez-Vázquez S, Lavilla R, González-Barca EM, Pons G, Gil J. Cosialls AM, et al. Among authors: saura esteller j. Biochem Pharmacol. 2020 Oct;180:114198. doi: 10.1016/j.bcp.2020.114198. Epub 2020 Aug 13. Biochem Pharmacol. 2020. PMID: 32798467
Fluorizoline-induced apoptosis requires prohibitins in nematodes and human cells.
Saura-Esteller J, Sánchez-Vera I, Núñez-Vázquez S, Jabalquinto-Carrasco J, Cosialls AM, Mendive-Tapia L, Kukhtar D, Martínez-Bueno MD, Lavilla R, Cerón J, Artal-Sanz M, Pons G, Iglesias-Serret D, Gil J. Saura-Esteller J, et al. Apoptosis. 2021 Feb;26(1-2):83-95. doi: 10.1007/s10495-020-01651-z. Epub 2021 Jan 2. Apoptosis. 2021. PMID: 33387147
Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines.
Saura-Esteller J, Sánchez-Vera I, Núñez-Vázquez S, Cosialls AM, Gama-Pérez P, Bhosale G, Mendive-Tapia L, Lavilla R, Pons G, Garcia-Roves PM, Duchen MR, Iglesias-Serret D, Gil J. Saura-Esteller J, et al. Int J Mol Sci. 2021 Jun 6;22(11):6117. doi: 10.3390/ijms22116117. Int J Mol Sci. 2021. PMID: 34204139 Free PMC article.
The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells.
Núñez-Vázquez S, Saura-Esteller J, Sánchez-Vera I, Guilbaud E, Cosialls AM, Pons G, Ricci JE, Iglesias-Serret D, Marchetti S, Gil J. Núñez-Vázquez S, et al. Among authors: saura esteller j. Oncogenesis. 2021 Sep 27;10(9):64. doi: 10.1038/s41389-021-00352-9. Oncogenesis. 2021. PMID: 34580273 Free PMC article.
12 results