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ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.
Hanson A, Elpek K, Duong E, Shallberg L, Fan M, Johnson C, Wallace M, Mabry GR, Sazinsky S, Pepper L, Shu CJ, Sathyanarayanan S, Zuerndorfer S, Simpson T, Gostissa M, Briskin M, Law D, Michaelson J, Harvey CJ. Hanson A, et al. Among authors: sathyanarayanan s. PLoS One. 2020 Sep 24;15(9):e0239595. doi: 10.1371/journal.pone.0239595. eCollection 2020. PLoS One. 2020. PMID: 32970735 Free PMC article.
Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity.
Kamerkar S, Leng C, Burenkova O, Jang SC, McCoy C, Zhang K, Dooley K, Kasera S, Zi T, Sisó S, Dahlberg W, Sia CL, Patel S, Schmidt K, Economides K, Soos T, Burzyn D, Sathyanarayanan S. Kamerkar S, et al. Among authors: sathyanarayanan s. Sci Adv. 2022 Feb 18;8(7):eabj7002. doi: 10.1126/sciadv.abj7002. Epub 2022 Feb 18. Sci Adv. 2022. PMID: 35179953 Free PMC article.
Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12.
Lewis ND, Sia CL, Kirwin K, Haupt S, Mahimkar G, Zi T, Xu K, Dooley K, Jang SC, Choi B, Boutin A, Grube A, McCoy C, Sanchez-Salazar J, Doherty M, Gaidukov L, Estes S, Economides KD, Williams DE, Sathyanarayanan S. Lewis ND, et al. Among authors: sathyanarayanan s. Mol Cancer Ther. 2021 Mar;20(3):523-534. doi: 10.1158/1535-7163.MCT-20-0484. Epub 2020 Dec 21. Mol Cancer Ther. 2021. PMID: 33443094
Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors.
Zhang W, Haines BB, Efferson C, Zhu J, Ware C, Kunii K, Tammam J, Angagaw M, Hinton MC, Keilhack H, Paweletz CP, Zhang T, Winter C, Sathyanarayanan S, Cheng J, Zawel L, Fawell S, Gilliland G, Majumder PK. Zhang W, et al. Among authors: sathyanarayanan s. Transl Oncol. 2012 Dec;5(6):422-9. doi: 10.1593/tlo.12241. Epub 2012 Dec 1. Transl Oncol. 2012. PMID: 23323157 Free PMC article.
ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance.
Jang SC, Economides KD, Moniz RJ, Sia CL, Lewis N, McCoy C, Zi T, Zhang K, Harrison RA, Lim J, Dey J, Grenley M, Kirwin K, Ross NL, Bourdeau R, Villiger-Oberbek A, Estes S, Xu K, Sanchez-Salazar J, Dooley K, Dahlberg WK, Williams DE, Sathyanarayanan S. Jang SC, et al. Among authors: sathyanarayanan s. Commun Biol. 2021 Apr 22;4(1):497. doi: 10.1038/s42003-021-02004-5. Commun Biol. 2021. PMID: 33888863 Free PMC article.
Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors.
Andersen JN, Sathyanarayanan S, Di Bacco A, Chi A, Zhang T, Chen AH, Dolinski B, Kraus M, Roberts B, Arthur W, Klinghoffer RA, Gargano D, Li L, Feldman I, Lynch B, Rush J, Hendrickson RC, Blume-Jensen P, Paweletz CP. Andersen JN, et al. Among authors: sathyanarayanan s. Sci Transl Med. 2010 Aug 4;2(43):43ra55. doi: 10.1126/scitranslmed.3001065. Sci Transl Med. 2010. PMID: 20686178
Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.
Stoeck A, Lejnine S, Truong A, Pan L, Wang H, Zang C, Yuan J, Ware C, MacLean J, Garrett-Engele PW, Kluk M, Laskey J, Haines BB, Moskaluk C, Zawel L, Fawell S, Gilliland G, Zhang T, Kremer BE, Knoechel B, Bernstein BE, Pear WS, Liu XS, Aster JC, Sathyanarayanan S. Stoeck A, et al. Among authors: sathyanarayanan s. Cancer Discov. 2014 Oct;4(10):1154-67. doi: 10.1158/2159-8290.CD-13-0830. Epub 2014 Aug 7. Cancer Discov. 2014. PMID: 25104330 Free PMC article.
58 results