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Regulation of the Methylation and Expression Levels of the BMPR2 Gene by SIN3a as a Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension.
Bisserier M, Mathiyalagan P, Zhang S, Elmastour F, Dorfmüller P, Humbert M, David G, Tarzami S, Weber T, Perros F, Sassi Y, Sahoo S, Hadri L. Bisserier M, et al. Among authors: sassi y. Circulation. 2021 Jul 6;144(1):52-73. doi: 10.1161/CIRCULATIONAHA.120.047978. Epub 2021 Jun 3. Circulation. 2021. PMID: 34078089 Free PMC article.
Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension.
Bisserier M, Katz MG, Bueno-Beti C, Brojakowska A, Zhang S, Gubara S, Kohlbrenner E, Fazal S, Fargnoli A, Dorfmuller P, Humbert M, Hata A, Goukassian DA, Sassi Y, Hadri L. Bisserier M, et al. Among authors: sassi y. Int J Mol Sci. 2021 Aug 24;22(17):9105. doi: 10.3390/ijms22179105. Int J Mol Sci. 2021. PMID: 34502015 Free PMC article.
FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair.
Mathiyalagan P, Adamiak M, Mayourian J, Sassi Y, Liang Y, Agarwal N, Jha D, Zhang S, Kohlbrenner E, Chepurko E, Chen J, Trivieri MG, Singh R, Bouchareb R, Fish K, Ishikawa K, Lebeche D, Hajjar RJ, Sahoo S. Mathiyalagan P, et al. Among authors: sassi y. Circulation. 2019 Jan 22;139(4):518-532. doi: 10.1161/CIRCULATIONAHA.118.033794. Circulation. 2019. PMID: 29997116 Free PMC article.
Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension.
Strauss B, Sassi Y, Bueno-Beti C, Ilkan Z, Raad N, Cacheux M, Bisserier M, Turnbull IC, Kohlbrenner E, Hajjar RJ, Hadri L, Akar FG. Strauss B, et al. Among authors: sassi y. J Mol Cell Cardiol. 2019 Feb;127:20-30. doi: 10.1016/j.yjmcc.2018.11.017. Epub 2018 Nov 28. J Mol Cell Cardiol. 2019. PMID: 30502350 Free PMC article.
AAV1.SERCA2a Gene Therapy Reverses Pulmonary Fibrosis by Blocking the STAT3/FOXM1 Pathway and Promoting the SNON/SKI Axis.
Bisserier M, Milara J, Abdeldjebbar Y, Gubara S, Jones C, Bueno-Beti C, Chepurko E, Kohlbrenner E, Katz MG, Tarzami S, Cortijo J, Leopold J, Hajjar RJ, Sassi Y, Hadri L. Bisserier M, et al. Among authors: sassi y. Mol Ther. 2020 Feb 5;28(2):394-410. doi: 10.1016/j.ymthe.2019.11.027. Epub 2019 Dec 6. Mol Ther. 2020. PMID: 31879190 Free PMC article.
Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice.
Hara Y, Sassi Y, Guibert C, Gambaryan N, Dorfmüller P, Eddahibi S, Lompré AM, Humbert M, Hulot JS. Hara Y, et al. Among authors: sassi y. J Clin Invest. 2011 Jul;121(7):2888-97. doi: 10.1172/JCI45023. Epub 2011 Jun 13. J Clin Invest. 2011. PMID: 21670499 Free PMC article.
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