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ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes.
Miki K, Deguchi K, Nakanishi-Koakutsu M, Lucena-Cacace A, Kondo S, Fujiwara Y, Hatani T, Sasaki M, Naka Y, Okubo C, Narita M, Takei I, Napier SC, Sugo T, Imaichi S, Monjo T, Ando T, Tamura N, Imahashi K, Nishimoto T, Yoshida Y. Miki K, et al. Among authors: sasaki m. Nat Commun. 2021 Jun 21;12(1):3596. doi: 10.1038/s41467-021-23816-3. Nat Commun. 2021. PMID: 34155205 Free PMC article.
ERRγ agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation.
Fujiwara Y, Miki K, Deguchi K, Naka Y, Sasaki M, Sakoda A, Narita M, Imaichi S, Sugo T, Funakoshi S, Nishimoto T, Imahashi K, Yoshida Y. Fujiwara Y, et al. Among authors: sasaki m. Stem Cell Reports. 2023 Nov 14;18(11):2108-2122. doi: 10.1016/j.stemcr.2023.09.003. Epub 2023 Oct 5. Stem Cell Reports. 2023. PMID: 37802074 Free PMC article.
Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors.
Mizojiri R, Asano M, Tomita D, Banno H, Nii N, Sasaki M, Sumi H, Satoh Y, Yamamoto Y, Moriya T, Satomi Y, Maezaki H. Mizojiri R, et al. Among authors: sasaki m. J Med Chem. 2018 Feb 8;61(3):1098-1117. doi: 10.1021/acs.jmedchem.7b01547. Epub 2018 Jan 5. J Med Chem. 2018. PMID: 29232514
Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors.
Kamata M, Yamashita T, Kina A, Tawada M, Endo S, Mizukami A, Sasaki M, Tani A, Nakano Y, Watanabe Y, Furuyama N, Funami M, Amano N, Fukatsu K. Kamata M, et al. Among authors: sasaki m. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4769-72. doi: 10.1016/j.bmcl.2012.05.062. Epub 2012 May 19. Bioorg Med Chem Lett. 2012. PMID: 22677317
Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity.
Ikeda Z, Kakegawa K, Kikuchi F, Itono S, Oki H, Yashiro H, Hiyoshi H, Tsuchimori K, Hamagami K, Watanabe M, Sasaki M, Ishihara Y, Tohyama K, Kitazaki T, Maekawa T, Sasaki M. Ikeda Z, et al. Among authors: sasaki m. J Med Chem. 2022 Jun 23;65(12):8456-8477. doi: 10.1021/acs.jmedchem.2c00463. Epub 2022 Jun 10. J Med Chem. 2022. PMID: 35686954 Free PMC article.
Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554.
Maezaki H, Banno Y, Miyamoto Y, Moritoh Y, Asakawa T, Kataoka O, Takeuchi K, Suzuki N, Ikedo K, Kosaka T, Sasaki M, Tsubotani S, Tani A, Funami M, Yamamoto Y, Tawada M, Aertgeerts K, Yano J, Oi S. Maezaki H, et al. Among authors: sasaki m. Bioorg Med Chem. 2011 Aug 1;19(15):4482-98. doi: 10.1016/j.bmc.2011.06.032. Epub 2011 Jul 7. Bioorg Med Chem. 2011. PMID: 21741847
5,953 results