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Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model.
Nat Commun. 2024 Jan 10;15(1):447. doi: 10.1038/s41467-024-44732-2.
Nat Commun. 2024.
PMID: 38200091
Free PMC article.
Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson's disease.
Wang Q, Wang M, Choi I, Sarrafha L, Liang M, Ho L, Farrell K, Beaumont KG, Sebra R, De Sanctis C, Crary JF, Ahfeldt T, Blanchard J, Neavin D, Powell J, Davis DA, Sun X, Zhang B, Yue Z.
Wang Q, et al. Among authors: sarrafha l.
Sci Adv. 2024 Jan 12;10(2):eadi8287. doi: 10.1126/sciadv.adi8287. Epub 2024 Jan 10.
Sci Adv. 2024.
PMID: 38198537
Free PMC article.
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Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversity.
Sarrafha L, Neavin DR, Parfitt GM, Kruglikov IA, Whitney K, Reyes R, Coccia E, Kareva T, Goldman C, Tipon R, Croft G, Crary JF, Powell JE, Blanchard J, Ahfeldt T.
Sarrafha L, et al.
iScience. 2023 Aug 2;26(9):107525. doi: 10.1016/j.isci.2023.107525. eCollection 2023 Sep 15.
iScience. 2023.
PMID: 37646018
Free PMC article.
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A reference human induced pluripotent stem cell line for large-scale collaborative studies.
Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, Oguro H, Kanaujiya J, Zou J, Sebesta D, Pratt G, Cross E, Blockwick J, Buxton P, Kinner-Bibeau L, Medura C, Tompkins C, Hughes S, Santiana M, Faghri F, Nalls MA, Vitale D, Ballard S, Qi YA, Ramos DM, Anderson KM, Stadler J, Narayan P, Papademetriou J, Reilly L, Nelson MP, Aggarwal S, Rosen LU, Kirwan P, Pisupati V, Coon SL, Scholz SW, Priebe T, Öttl M, Dong J, Meijer M, Janssen LJM, Lourenco VS, van der Kant R, Crusius D, Paquet D, Raulin AC, Bu G, Held A, Wainger BJ, Gabriele RMC, Casey JM, Wray S, Abu-Bonsrah D, Parish CL, Beccari MS, Cleveland DW, Li E, Rose IVL, Kampmann M, Calatayud Aristoy C, Verstreken P, Heinrich L, Chen MY, Schüle B, Dou D, Holzbaur ELF, Zanellati MC, Basundra R, Deshmukh M, Cohen S, Khanna R, Raman M, Nevin ZS, Matia M, Van Lent J, Timmerman V, Conklin BR, Johnson Chase K, Zhang K, Funes S, Bosco DA, Erlebach L, Welzer M, Kronenberg-Versteeg D, Lyu G, Arenas E, Coccia E, Sarrafha L, Ahfeldt T, Marioni JC, Skarnes WC, Cookson MR, Ward ME, Merkle FT.
Pantazis CB, et al. Among authors: sarrafha l.
Cell Stem Cell. 2022 Dec 1;29(12):1685-1702.e22. doi: 10.1016/j.stem.2022.11.004.
Cell Stem Cell. 2022.
PMID: 36459969
Free PMC article.
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High-throughput generation of midbrain dopaminergic neuron organoids from reporter human pluripotent stem cells.
Sarrafha L, Parfitt GM, Reyes R, Goldman C, Coccia E, Kareva T, Ahfeldt T.
Sarrafha L, et al.
STAR Protoc. 2021 Apr 19;2(2):100463. doi: 10.1016/j.xpro.2021.100463. eCollection 2021 Jun 18.
STAR Protoc. 2021.
PMID: 33997803
Free PMC article.
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Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons.
Ahfeldt T, Ordureau A, Bell C, Sarrafha L, Sun C, Piccinotti S, Grass T, Parfitt GM, Paulo JA, Yanagawa F, Uozumi T, Kiyota Y, Harper JW, Rubin LL.
Ahfeldt T, et al. Among authors: sarrafha l.
Stem Cell Reports. 2020 Jan 14;14(1):75-90. doi: 10.1016/j.stemcr.2019.12.005. Epub 2020 Jan 2.
Stem Cell Reports. 2020.
PMID: 31902706
Free PMC article.
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