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Intestinal, but not hepatic, ChREBP is required for fructose tolerance.
Kim M, Astapova II, Flier SN, Hannou SA, Doridot L, Sargsyan A, Kou HH, Fowler AJ, Liang G, Herman MA. Kim M, et al. Among authors: sargsyan a. JCI Insight. 2017 Dec 21;2(24):e96703. doi: 10.1172/jci.insight.96703. JCI Insight. 2017. PMID: 29263303 Free PMC article.
The intestine is a major contributor to circulating succinate in mice.
Tong W, Hannou SA, Wang Y, Astapova I, Sargsyan A, Monn R, Thiriveedi V, Li D, McCann JR, Rawls JF, Roper J, Zhang GF, Herman MA. Tong W, et al. Among authors: sargsyan a. FASEB J. 2022 Oct;36(10):e22546. doi: 10.1096/fj.202200135RR. FASEB J. 2022. PMID: 36106538 Free PMC article.
HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
Sargsyan A, Doridot L, Hannou SA, Tong W, Srinivasan H, Ivison R, Monn R, Kou HH, Haldeman JM, Arlotto M, White PJ, Grimsrud PA, Astapova I, Tsai LT, Herman MA. Sargsyan A, et al. JCI Insight. 2023 Jan 10;8(1):e153740. doi: 10.1172/jci.insight.153740. JCI Insight. 2023. PMID: 36413406 Free PMC article.
Liver retinol transporter and receptor for serum retinol-binding protein (RBP4).
Alapatt P, Guo F, Komanetsky SM, Wang S, Cai J, Sargsyan A, Rodríguez Díaz E, Bacon BT, Aryal P, Graham TE. Alapatt P, et al. Among authors: sargsyan a. J Biol Chem. 2013 Jan 11;288(2):1250-65. doi: 10.1074/jbc.M112.369132. Epub 2012 Oct 26. J Biol Chem. 2013. PMID: 23105095 Free PMC article.
Hepatocytes Are the Principal Source of Circulating RBP4 in Mice.
Thompson SJ, Sargsyan A, Lee SA, Yuen JJ, Cai J, Smalling R, Ghyselinck N, Mark M, Blaner WS, Graham TE. Thompson SJ, et al. Among authors: sargsyan a. Diabetes. 2017 Jan;66(1):58-63. doi: 10.2337/db16-0286. Epub 2016 Oct 19. Diabetes. 2017. PMID: 27797907 Free PMC article.
Endothelial Cell Autophagy Maintains Shear Stress-Induced Nitric Oxide Generation via Glycolysis-Dependent Purinergic Signaling to Endothelial Nitric Oxide Synthase.
Bharath LP, Cho JM, Park SK, Ruan T, Li Y, Mueller R, Bean T, Reese V, Richardson RS, Cai J, Sargsyan A, Pires K, Anandh Babu PV, Boudina S, Graham TE, Symons JD. Bharath LP, et al. Among authors: sargsyan a. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1646-1656. doi: 10.1161/ATVBAHA.117.309510. Epub 2017 Jul 6. Arterioscler Thromb Vasc Biol. 2017. PMID: 28684613 Free PMC article.
163 results