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Discovery of Nanomolar DCAF1 Small Molecule Ligands.
Li ASM, Kimani S, Wilson B, Noureldin M, González-Álvarez H, Mamai A, Hoffer L, Guilinger JP, Zhang Y, von Rechenberg M, Disch JS, Mulhern CJ, Slakman BL, Cuozzo JW, Dong A, Poda G, Mohammed M, Saraon P, Mittal M, Modh P, Rathod V, Patel B, Ackloo S, Santhakumar V, Szewczyk MM, Barsyte-Lovejoy D, Arrowsmith CH, Marcellus R, Guié MA, Keefe AD, Brown PJ, Halabelian L, Al-Awar R, Vedadi M. Li ASM, et al. Among authors: saraon p. J Med Chem. 2023 Apr 13;66(7):5041-5060. doi: 10.1021/acs.jmedchem.2c02132. Epub 2023 Mar 22. J Med Chem. 2023. PMID: 36948210 Free PMC article.
Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells.
Saraon P, Snider J, Schormann W, Rai A, Radulovich N, Sánchez-Osuna M, Coulombe-Huntington J, Huard C, Mohammed M, Lima-Fernandes E, Thériault B, Halabelian L, Chan M, Joshi D, Drecun L, Yao Z, Pathmanathan S, Wong V, Lyakisheva A, Aboualizadeh F, Niu L, Li F, Kiyota T, Subramanian R, Joseph B, Aman A, Prakesch M, Isaac M, Mamai A, Poda G, Vedadi M, Marcellus R, Uehling D, Leighl N, Sacher A, Samaržija M, Jakopović M, Arrowsmith C, Tyers M, Tsao MS, Andrews D, Al-Awar R, Stagljar I. Saraon P, et al. J Mol Biol. 2021 Nov 19;433(23):167294. doi: 10.1016/j.jmb.2021.167294. Epub 2021 Oct 16. J Mol Biol. 2021. PMID: 34662547
Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis.
Kim MJ, Febbraro D, Farkona S, Gillmore T, Son JE, Regeenes R, Chang HH, Pollock-Tahiri E, Yang J, Park YJ, Sivasubramaniyam T, Oh SJ, Saraon P, Stagljar I, Rocheleau JV, Hui CC, Caniggia I, Hao Z, Mak TW, Konvalinka A, Woo M. Kim MJ, et al. Among authors: saraon p. Mol Metab. 2021 May;47:101185. doi: 10.1016/j.molmet.2021.101185. Epub 2021 Feb 6. Mol Metab. 2021. PMID: 33561544 Free PMC article.
A drug discovery platform to identify compounds that inhibit EGFR triple mutants.
Saraon P, Snider J, Kalaidzidis Y, Wybenga-Groot LE, Weiss K, Rai A, Radulovich N, Drecun L, Vučković N, Vučetić A, Wong V, Thériault B, Pham NA, Park JH, Datti A, Wang J, Pathmanathan S, Aboualizadeh F, Lyakisheva A, Yao Z, Wang Y, Joseph B, Aman A, Moran MF, Prakesch M, Poda G, Marcellus R, Uehling D, Samaržija M, Jakopović M, Tsao MS, Shepherd FA, Sacher A, Leighl N, Akhmanova A, Al-Awar R, Zerial M, Stagljar I. Saraon P, et al. Nat Chem Biol. 2020 May;16(5):577-586. doi: 10.1038/s41589-020-0484-2. Epub 2020 Feb 24. Nat Chem Biol. 2020. PMID: 32094923 Free PMC article.
Multi-omics Biomarker Pipeline Reveals Elevated Levels of Protein-glutamine Gamma-glutamyltransferase 4 in Seminal Plasma of Prostate Cancer Patients.
Drabovich AP, Saraon P, Drabovich M, Karakosta TD, Dimitromanolakis A, Hyndman ME, Jarvi K, Diamandis EP. Drabovich AP, et al. Among authors: saraon p. Mol Cell Proteomics. 2019 Sep;18(9):1807-1823. doi: 10.1074/mcp.RA119.001612. Epub 2019 Jun 27. Mol Cell Proteomics. 2019. PMID: 31249104 Free PMC article.
Testing cancer inhibitors at scale.
Saraon P, Grozavu I, Stagljar I. Saraon P, et al. Nat Biomed Eng. 2018 Apr;2(4):203-204. doi: 10.1038/s41551-018-0226-x. Nat Biomed Eng. 2018. PMID: 30936440 No abstract available.
Fundamentals of protein interaction network mapping.
Snider J, Kotlyar M, Saraon P, Yao Z, Jurisica I, Stagljar I. Snider J, et al. Among authors: saraon p. Mol Syst Biol. 2015 Dec 17;11(12):848. doi: 10.15252/msb.20156351. Mol Syst Biol. 2015. PMID: 26681426 Free PMC article. Review.
28 results