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Aspartic vinyl sulfones: inhibitors of a caspase-3-dependent pathway.
Glória PM, Coutinho I, Gonçalves LM, Baptista C, Soares J, Newton AS, Moreira R, Saraiva L, Santos MM. Glória PM, et al. Among authors: saraiva l. Eur J Med Chem. 2011 Jun;46(6):2141-6. doi: 10.1016/j.ejmech.2011.02.067. Epub 2011 Mar 5. Eur J Med Chem. 2011. PMID: 21439692
Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction.
Soares J, Pereira NA, Monteiro Â, Leão M, Bessa C, Dos Santos DJ, Raimundo L, Queiroz G, Bisio A, Inga A, Pereira C, Santos MM, Saraiva L. Soares J, et al. Among authors: saraiva l. Eur J Pharm Sci. 2015 Jan 23;66:138-47. doi: 10.1016/j.ejps.2014.10.006. Epub 2014 Oct 13. Eur J Pharm Sci. 2015. PMID: 25312347
Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule.
Soares J, Raimundo L, Pereira NA, Monteiro Â, Gomes S, Bessa C, Pereira C, Queiroz G, Bisio A, Fernandes J, Gomes C, Reis F, Gonçalves J, Inga A, Santos MM, Saraiva L. Soares J, et al. Among authors: saraiva l. Oncotarget. 2016 Jan 26;7(4):4326-43. doi: 10.18632/oncotarget.6775. Oncotarget. 2016. PMID: 26735173 Free PMC article.
p53 family interactions and yeast: together in anticancer therapy.
Gomes S, Leão M, Raimundo L, Ramos H, Soares J, Saraiva L. Gomes S, et al. Among authors: saraiva l. Drug Discov Today. 2016 Apr;21(4):616-24. doi: 10.1016/j.drudis.2016.02.007. Epub 2016 Feb 15. Drug Discov Today. 2016. PMID: 26891980 Review.
Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.
Bessa C, Soares J, Raimundo L, Loureiro JB, Gomes C, Reis F, Soares ML, Santos D, Dureja C, Chaudhuri SR, Lopez-Haber C, Kazanietz MG, Gonçalves J, Simões MF, Rijo P, Saraiva L. Bessa C, et al. Among authors: saraiva l. Cell Death Dis. 2018 Jan 18;9(2):23. doi: 10.1038/s41419-017-0154-9. Cell Death Dis. 2018. PMID: 29348560 Free PMC article.
428 results