Sarafianos SG - Search Results

1

Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.

Vernekar SKV, Tang J, Wu B, Huber AD, Casey MC, Myshakina N, Wilson DJ, Kankanala J, Kirby KA, Parniak MA, Sarafianos SG, Wang Z. Vernekar SKV, et al. Among authors: sarafianos sg. J Med Chem. 2017 Jun 22;60(12):5045-5056. doi: 10.1021/acs.jmedchem.7b00440. Epub 2017 May 31. J Med Chem. 2017. PMID: 28525279 Free PMC article.

2

HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.

Himmel DM, Sarafianos SG, Dharmasena S, Hossain MM, McCoy-Simandle K, Ilina T, Clark AD Jr, Knight JL, Julias JG, Clark PK, Krogh-Jespersen K, Levy RM, Hughes SH, Parniak MA, Arnold E. Himmel DM, et al. Among authors: sarafianos sg. ACS Chem Biol. 2006 Dec 20;1(11):702-12. doi: 10.1021/cb600303y. ACS Chem Biol. 2006. PMID: 17184135 Free PMC article.

3

3'-Azido-3'-deoxythymidine-(5')-tetraphospho-(5')-adenosine, the product of ATP-mediated excision of chain-terminating AZTMP, is a potent chain-terminating substrate for HIV-1 reverse transcriptase.

Dharmasena S, Pongracz Z, Arnold E, Sarafianos SG, Parniak MA. Dharmasena S, et al. Among authors: sarafianos sg. Biochemistry. 2007 Jan 23;46(3):828-36. doi: 10.1021/bi061364s. Biochemistry. 2007. PMID: 17223704

4

Synthesis of AZTpSpCX2ppSA and AZTpSpCX2ppSAZT: hydrolysis-resistant potential inhibitors of the AZT excision reaction of HIV-1 RT.

Han Q, Sarafianos SG, Arnold E, Parniak MA, Gaffney BL, Jones RA. Han Q, et al. Among authors: sarafianos sg. Org Lett. 2007 Dec 6;9(25):5243-6. doi: 10.1021/ol7023746. Epub 2007 Nov 8. Org Lett. 2007. PMID: 17988141

5

Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.

Sarafianos SG, Marchand B, Das K, Himmel DM, Parniak MA, Hughes SH, Arnold E. Sarafianos SG, et al. J Mol Biol. 2009 Jan 23;385(3):693-713. doi: 10.1016/j.jmb.2008.10.071. Epub 2008 Nov 3. J Mol Biol. 2009. PMID: 19022262 Free PMC article. Review.

6

Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.

Michailidis E, Marchand B, Kodama EN, Singh K, Matsuoka M, Kirby KA, Ryan EM, Sawani AM, Nagy E, Ashida N, Mitsuya H, Parniak MA, Sarafianos SG. Michailidis E, et al. Among authors: sarafianos sg. J Biol Chem. 2009 Dec 18;284(51):35681-91. doi: 10.1074/jbc.M109.036616. J Biol Chem. 2009. PMID: 19837673 Free PMC article.

7

The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site.

Abram ME, Sarafianos SG, Parniak MA. Abram ME, et al. Among authors: sarafianos sg. Retrovirology. 2010 Feb 1;7:6. doi: 10.1186/1742-4690-7-6. Retrovirology. 2010. PMID: 20122159 Free PMC article.

8

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase.

Singh K, Marchand B, Kirby KA, Michailidis E, Sarafianos SG. Singh K, et al. Among authors: sarafianos sg. Viruses. 2010 Feb 11;2(2):606-638. doi: 10.3390/v2020606. Viruses. 2010. PMID: 20376302 Free PMC article.

9

Synthesis of Boranoate, Selenoate, and Thioate Analogs of AZTp(4)A and Ap(4)A.

Han Q, Sarafianos SG, Arnold E, Parniak MA, Gaffney BL, Jones RA. Han Q, et al. Among authors: sarafianos sg. Tetrahedron. 2009 Sep 19;65(38):7915-7920. doi: 10.1016/j.tet.2009.07.079. Tetrahedron. 2009. PMID: 20625456 Free PMC article.

10

The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine.

Schuckmann MM, Marchand B, Hachiya A, Kodama EN, Kirby KA, Singh K, Sarafianos SG. Schuckmann MM, et al. Among authors: sarafianos sg. J Biol Chem. 2010 Dec 3;285(49):38700-9. doi: 10.1074/jbc.M110.153783. Epub 2010 Sep 27. J Biol Chem. 2010. PMID: 20876531 Free PMC article.

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