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Metabolic activation enhances the cytotoxicity, genotoxicity and mutagenicity of two synthetic alkaloids with selective effects against human tumour cell lines.
Oliveira JT, Franco FN, Tecchio KB, Gonçalves AMMN, Barbosa CS, Ribeiro RIMA, Viana GHR, Santos VJDSVD, Santos FVD. Oliveira JT, et al. Among authors: santos fvd. Mutat Res Genet Toxicol Environ Mutagen. 2021 Jan-Feb;861-862:503294. doi: 10.1016/j.mrgentox.2020.503294. Epub 2020 Nov 7. Mutat Res Genet Toxicol Environ Mutagen. 2021. PMID: 33551097 Free article.
Synthesis and evaluation of the mutagenicity of 3-alkylpyridine marine alkaloid analogues with anticancer potential.
Barbosa MCS, de Souza Barbosa C, de Oliveira JT, Moreira NCS, de Miranda Martins NR, Alves Gomes GK, Caldeira CA, Alves E Costa ML, Martins Guimarães DS, Guimarães L, Nascimento CS Jr, de Pilla Varotti F, Ribeiro Viana GH, Santos FVD. Barbosa MCS, et al. Among authors: santos fvd. Mutat Res Genet Toxicol Environ Mutagen. 2018 Jan;825:31-39. doi: 10.1016/j.mrgentox.2017.11.006. Epub 2017 Nov 24. Mutat Res Genet Toxicol Environ Mutagen. 2018. PMID: 29307373
γ-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effect.
Alves SLG, Paixão N, Ferreira LGR, Santos FRS, Neves LDR, Oliveira GC, Cortes VF, Salomé KS, Barison A, Santos FV, Cenzi G, Varotti FP, Oliveira SMF, Taranto AG, Comar M, Silva LM, Noël F, Quintas LEM, Barbosa LA, Villar JAFP. Alves SLG, et al. Bioorg Med Chem. 2015 Aug 1;23(15):4397-4404. doi: 10.1016/j.bmc.2015.06.028. Epub 2015 Jun 17. Bioorg Med Chem. 2015. PMID: 26122772 Free article.
21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions.
Rocha SC, Pessoa MT, Neves LD, Alves SL, Silva LM, Santos HL, Oliveira SM, Taranto AG, Comar M, Gomes IV, Santos FV, Paixão N, Quintas LE, Noël F, Pereira AF, Tessis AC, Gomes NL, Moreira OC, Rincon-Heredia R, Varotti FP, Blanco G, Villar JA, Contreras RG, Barbosa LA. Rocha SC, et al. PLoS One. 2014 Oct 7;9(10):e108776. doi: 10.1371/journal.pone.0108776. eCollection 2014. PLoS One. 2014. PMID: 25290152 Free PMC article.
12 results