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Designed multiple ligands for the treatment of type 2 diabetes mellitus and its complications: Discovery of (5-arylidene-4-oxo-2-thioxothiazolidin-3-yl)alkanoic acids active as novel dual-targeted PTP1B/AKR1B1 inhibitors.
Maccari R, Wolber G, Genovese M, Sardelli G, Talagayev V, Balestri F, Luti S, Santi A, Moschini R, Del Corso A, Paoli P, Ottanà R. Maccari R, et al. Among authors: santi a. Eur J Med Chem. 2023 Apr 5;252:115270. doi: 10.1016/j.ejmech.2023.115270. Epub 2023 Mar 14. Eur J Med Chem. 2023. PMID: 36934484 Free article.
The effects of CA IX catalysis products within tumor microenvironment.
Santi A, Caselli A, Paoli P, Corti D, Camici G, Pieraccini G, Taddei ML, Serni S, Chiarugi P, Cirri P. Santi A, et al. Cell Commun Signal. 2013 Oct 29;11:81. doi: 10.1186/1478-811X-11-81. Cell Commun Signal. 2013. PMID: 24168032 Free PMC article.
Morin: A Promising Natural Drug.
Caselli A, Cirri P, Santi A, Paoli P. Caselli A, et al. Among authors: santi a. Curr Med Chem. 2016;23(8):774-91. doi: 10.2174/0929867323666160106150821. Curr Med Chem. 2016. PMID: 26018232 Review.
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity.
Sblano S, Cerchia C, Laghezza A, Piemontese L, Brunetti L, Leuci R, Gilardi F, Thomas A, Genovese M, Santi A, Tortorella P, Paoli P, Lavecchia A, Loiodice F. Sblano S, et al. Among authors: santi a. Eur J Med Chem. 2022 May 5;235:114240. doi: 10.1016/j.ejmech.2022.114240. Epub 2022 Mar 16. Eur J Med Chem. 2022. PMID: 35325635
249 results