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Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz TD, Pinch BJ, Akshinthala D, Verma A, Gaglia G, Nezu Y, Ke S, Qiu C, Ohuchida K, Oda Y, Lee TH, Wegiel B, Clohessy JG, London N, Santagata S, Wulf GM, Hidalgo M, Muthuswamy SK, Nakamura M, Gray NS, Zhou XZ, Lu KP. Koikawa K, et al. Among authors: santagata s. Cell. 2021 Sep 2;184(18):4753-4771.e27. doi: 10.1016/j.cell.2021.07.020. Epub 2021 Aug 12. Cell. 2021. PMID: 34388391 Free PMC article.
Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation.
Jaeger AM, Stopfer L, Lee S, Gaglia G, Sandel D, Santagata S, Lin NU, Trepel JB, White F, Jacks T, Lindquist S, Whitesell L. Jaeger AM, et al. Among authors: santagata s. Clin Cancer Res. 2019 Nov 1;25(21):6392-6405. doi: 10.1158/1078-0432.CCR-19-0596. Epub 2019 Jun 18. Clin Cancer Res. 2019. PMID: 31213460 Free PMC article.
HSF1 phase transition mediates stress adaptation and cell fate decisions.
Gaglia G, Rashid R, Yapp C, Joshi GN, Li CG, Lindquist SL, Sarosiek KA, Whitesell L, Sorger PK, Santagata S. Gaglia G, et al. Among authors: santagata s. Nat Cell Biol. 2020 Feb;22(2):151-158. doi: 10.1038/s41556-019-0458-3. Epub 2020 Feb 3. Nat Cell Biol. 2020. PMID: 32015439 Free PMC article.
Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors.
Burger ML, Cruz AM, Crossland GE, Gaglia G, Ritch CC, Blatt SE, Bhutkar A, Canner D, Kienka T, Tavana SZ, Barandiaran AL, Garmilla A, Schenkel JM, Hillman M, de Los Rios Kobara I, Li A, Jaeger AM, Hwang WL, Westcott PMK, Manos MP, Holovatska MM, Hodi FS, Regev A, Santagata S, Jacks T. Burger ML, et al. Among authors: santagata s. Cell. 2021 Sep 16;184(19):4996-5014.e26. doi: 10.1016/j.cell.2021.08.020. Cell. 2021. PMID: 34534464 Free PMC article.
Temporal and spatial topography of cell proliferation in cancer.
Gaglia G, Kabraji S, Rammos D, Dai Y, Verma A, Wang S, Mills CE, Chung M, Bergholz JS, Coy S, Lin JR, Jeselsohn R, Metzger O, Winer EP, Dillon DA, Zhao JJ, Sorger PK, Santagata S. Gaglia G, et al. Among authors: santagata s. Nat Cell Biol. 2022 Mar;24(3):316-326. doi: 10.1038/s41556-022-00860-9. Epub 2022 Mar 15. Nat Cell Biol. 2022. PMID: 35292783 Free PMC article.
The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.
Scherz-Shouval R, Santagata S, Mendillo ML, Sholl LM, Ben-Aharon I, Beck AH, Dias-Santagata D, Koeva M, Stemmer SM, Whitesell L, Lindquist S. Scherz-Shouval R, et al. Among authors: santagata s. Cell. 2014 Jul 31;158(3):564-78. doi: 10.1016/j.cell.2014.05.045. Cell. 2014. PMID: 25083868 Free PMC article.
Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma.
Du Z, Abedalthagafi M, Aizer AA, McHenry AR, Sun HH, Bray MA, Viramontes O, Machaidze R, Brastianos PK, Reardon DA, Dunn IF, Freeman GJ, Ligon KL, Carpenter AE, Alexander BM, Agar NY, Rodig SJ, Bradshaw EM, Santagata S. Du Z, et al. Among authors: santagata s. Oncotarget. 2015 Mar 10;6(7):4704-16. doi: 10.18632/oncotarget.3082. Oncotarget. 2015. PMID: 25609200 Free PMC article.
260 results