Sankaran B - Search Results

1

Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.

Cohen I, Coban M, Shahar A, Sankaran B, Hockla A, Lacham S, Caulfield TR, Radisky ES, Papo N. Cohen I, et al. Among authors: sankaran b. J Biol Chem. 2019 Mar 29;294(13):5105-5120. doi: 10.1074/jbc.RA118.007292. Epub 2019 Jan 30. J Biol Chem. 2019. PMID: 30700553 Free PMC article.

2

A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring.

Casteel DE, Smith-Nguyen EV, Sankaran B, Roh SH, Pilz RB, Kim C. Casteel DE, et al. Among authors: sankaran b. J Biol Chem. 2010 Oct 22;285(43):32684-32688. doi: 10.1074/jbc.C110.161430. Epub 2010 Sep 8. J Biol Chem. 2010. PMID: 20826808 Free PMC article.

3

Crystal structure of the human fatty acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition.

Sippel KH, Vyas NK, Zhang W, Sankaran B, Quiocho FA. Sippel KH, et al. Among authors: sankaran b. J Biol Chem. 2014 Nov 28;289(48):33287-95. doi: 10.1074/jbc.M114.608547. Epub 2014 Oct 9. J Biol Chem. 2014. PMID: 25301948 Free PMC article.

4

A triple mutant in the Ω-loop of TEM-1 β-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis.

Stojanoski V, Chow DC, Hu L, Sankaran B, Gilbert HF, Prasad BV, Palzkill T. Stojanoski V, et al. Among authors: sankaran b. J Biol Chem. 2015 Apr 17;290(16):10382-94. doi: 10.1074/jbc.M114.633438. Epub 2015 Feb 20. J Biol Chem. 2015. PMID: 25713062 Free PMC article.

5

Mutational Constraints on Local Unfolding Inhibit the Rheological Adaptation of von Willebrand Factor.

Tischer A, Campbell JC, Machha VR, Moon-Tasson L, Benson LM, Sankaran B, Kim C, Auton M. Tischer A, et al. Among authors: sankaran b. J Biol Chem. 2016 Feb 19;291(8):3848-59. doi: 10.1074/jbc.M115.703850. Epub 2015 Dec 16. J Biol Chem. 2016. PMID: 26677223 Free PMC article.

6

Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.

Campbell JC, Kim JJ, Li KY, Huang GY, Reger AS, Matsuda S, Sankaran B, Link TM, Yuasa K, Ladbury JE, Casteel DE, Kim C. Campbell JC, et al. Among authors: sankaran b. J Biol Chem. 2016 Mar 11;291(11):5623-5633. doi: 10.1074/jbc.M115.691303. Epub 2016 Jan 14. J Biol Chem. 2016. PMID: 26769964 Free PMC article.

7

Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy.

Cohen I, Kayode O, Hockla A, Sankaran B, Radisky DC, Radisky ES, Papo N. Cohen I, et al. Among authors: sankaran b. Biochem J. 2016 May 15;473(10):1329-41. doi: 10.1042/BJ20151410. Epub 2016 Mar 8. Biochem J. 2016. PMID: 26957636 Free PMC article.

8

Structural basis for selective inhibition of human PKG Iα by the balanol-like compound N46.

Qin L, Sankaran B, Aminzai S, Casteel DE, Kim C. Qin L, et al. Among authors: sankaran b. J Biol Chem. 2018 Jul 13;293(28):10985-10992. doi: 10.1074/jbc.RA118.002427. Epub 2018 May 16. J Biol Chem. 2018. PMID: 29769318 Free PMC article.

9

Ab initio structure solution of a proteolytic fragment using ARCIMBOLDO.

Abendroth J, Sankaran B, Myler PJ, Lorimer DD, Edwards TE. Abendroth J, et al. Among authors: sankaran b. Acta Crystallogr F Struct Biol Commun. 2018 Sep 1;74(Pt 9):530-535. doi: 10.1107/S2053230X18010063. Epub 2018 Aug 29. Acta Crystallogr F Struct Biol Commun. 2018. PMID: 30198884 Free PMC article.

10

Synergistic effects of functionally distinct substitutions in β-lactamase variants shed light on the evolution of bacterial drug resistance.

Patel MP, Hu L, Brown CA, Sun Z, Adamski CJ, Stojanoski V, Sankaran B, Prasad BVV, Palzkill T. Patel MP, et al. Among authors: sankaran b. J Biol Chem. 2018 Nov 16;293(46):17971-17984. doi: 10.1074/jbc.RA118.003792. Epub 2018 Oct 1. J Biol Chem. 2018. PMID: 30275013 Free PMC article.

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