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Page 1
Gut microbes impact stroke severity via the trimethylamine N-oxide pathway.
Zhu W, Romano KA, Li L, Buffa JA, Sangwan N, Prakash P, Tittle AN, Li XS, Fu X, Androjna C, DiDonato AJ, Brinson K, Trapp BD, Fischbach MA, Rey FE, Hajjar AM, DiDonato JA, Hazen SL. Zhu W, et al. Among authors: sangwan n. Cell Host Microbe. 2021 Jul 14;29(7):1199-1208.e5. doi: 10.1016/j.chom.2021.05.002. Epub 2021 Jun 16. Cell Host Microbe. 2021. PMID: 34139173 Free PMC article.
CFTR dysregulation drives active selection of the gut microbiome.
Meeker SM, Mears KS, Sangwan N, Brittnacher MJ, Weiss EJ, Treuting PM, Tolley N, Pope CE, Hager KR, Vo AT, Paik J, Frevert CW, Hayden HS, Hoffman LR, Miller SI, Hajjar AM. Meeker SM, et al. Among authors: sangwan n. PLoS Pathog. 2020 Jan 21;16(1):e1008251. doi: 10.1371/journal.ppat.1008251. eCollection 2020 Jan. PLoS Pathog. 2020. PMID: 31961914 Free PMC article.
Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease.
Gupta N, Buffa JA, Roberts AB, Sangwan N, Skye SM, Li L, Ho KJ, Varga J, DiDonato JA, Tang WHW, Hazen SL. Gupta N, et al. Among authors: sangwan n. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1239-1255. doi: 10.1161/ATVBAHA.120.314139. Epub 2020 Mar 26. Arterioscler Thromb Vasc Biol. 2020. PMID: 32212854 Free PMC article.
Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism.
Pathak P, Helsley RN, Brown AL, Buffa JA, Choucair I, Nemet I, Gogonea CB, Gogonea V, Wang Z, Garcia-Garcia JC, Cai L, Temel R, Sangwan N, Hazen SL, Brown JM. Pathak P, et al. Among authors: sangwan n. Am J Physiol Heart Circ Physiol. 2020 Jun 1;318(6):H1474-H1486. doi: 10.1152/ajpheart.00584.2019. Epub 2020 Apr 24. Am J Physiol Heart Circ Physiol. 2020. PMID: 32330092 Free PMC article.
Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis.
Witkowski M, Witkowski M, Friebel J, Buffa JA, Li XS, Wang Z, Sangwan N, Li L, DiDonato JA, Tizian C, Haghikia A, Kirchhofer D, Mach F, Räber L, Matter CM, Tang WHW, Landmesser U, Lüscher TF, Rauch U, Hazen SL. Witkowski M, et al. Among authors: sangwan n. Cardiovasc Res. 2022 Jul 27;118(10):2367-2384. doi: 10.1093/cvr/cvab263. Cardiovasc Res. 2022. PMID: 34352109 Free PMC article.
The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota L-carnitine catabolism.
Buffa JA, Romano KA, Copeland MF, Cody DB, Zhu W, Galvez R, Fu X, Ward K, Ferrell M, Dai HJ, Skye S, Hu P, Li L, Parlov M, McMillan A, Wei X, Nemet I, Koeth RA, Li XS, Wang Z, Sangwan N, Hajjar AM, Dwidar M, Weeks TL, Bergeron N, Krauss RM, Tang WHW, Rey FE, DiDonato JA, Gogonea V, Gerberick GF, Garcia-Garcia JC, Hazen SL. Buffa JA, et al. Among authors: sangwan n. Nat Microbiol. 2022 Jan;7(1):73-86. doi: 10.1038/s41564-021-01010-x. Epub 2021 Dec 23. Nat Microbiol. 2022. PMID: 34949826 Free PMC article.
Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms.
Schugar RC, Gliniak CM, Osborn LJ, Massey W, Sangwan N, Horak A, Banerjee R, Orabi D, Helsley RN, Brown AL, Burrows A, Finney C, Fung KK, Allen FM, Ferguson D, Gromovsky AD, Neumann C, Cook K, McMillan A, Buffa JA, Anderson JT, Mehrabian M, Goudarzi M, Willard B, Mak TD, Armstrong AR, Swanson G, Keshavarzian A, Garcia-Garcia JC, Wang Z, Lusis AJ, Hazen SL, Brown JM. Schugar RC, et al. Among authors: sangwan n. Elife. 2022 Jan 24;11:e63998. doi: 10.7554/eLife.63998. Elife. 2022. PMID: 35072627 Free PMC article.
Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice.
Helsley RN, Miyata T, Kadam A, Varadharajan V, Sangwan N, Huang EC, Banerjee R, Brown AL, Fung KK, Massey WJ, Neumann C, Orabi D, Osborn LJ, Schugar RC, McMullen MR, Bellar A, Poulsen KL, Kim A, Pathak V, Mrdjen M, Anderson JT, Willard B, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Garcia-Garcia JC, Rotroff DM, Allende DS, Wang Z, Hazen SL, Nagy LE, Brown JM. Helsley RN, et al. Among authors: sangwan n. Elife. 2022 Jan 27;11:e76554. doi: 10.7554/eLife.76554. Elife. 2022. PMID: 35084335 Free PMC article.
Disruption of the Gut Microbiota Confers Cisplatin Resistance in Epithelial Ovarian Cancer.
Chambers LM, Esakov Rhoades EL, Bharti R, Braley C, Tewari S, Trestan L, Alali Z, Bayik D, Lathia JD, Sangwan N, Bazeley P, Joehlin-Price AS, Wang Z, Dutta S, Dwidar M, Hajjar A, Ahern PP, Claesen J, Rose P, Vargas R, Brown JM, Michener CM, Reizes O. Chambers LM, et al. Among authors: sangwan n. Cancer Res. 2022 Dec 16;82(24):4654-4669. doi: 10.1158/0008-5472.CAN-22-0455. Cancer Res. 2022. PMID: 36206317 Free PMC article.
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk.
Ferrell M, Wang Z, Anderson JT, Li XS, Witkowski M, DiDonato JA, Hilser JR, Hartiala JA, Haghikia A, Cajka T, Fiehn O, Sangwan N, Demuth I, König M, Steinhagen-Thiessen E, Landmesser U, Tang WHW, Allayee H, Hazen SL. Ferrell M, et al. Among authors: sangwan n. Nat Med. 2024 Feb;30(2):424-434. doi: 10.1038/s41591-023-02793-8. Epub 2024 Feb 19. Nat Med. 2024. PMID: 38374343
188 results