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Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia.
Membrez M, Migliavacca E, Christen S, Yaku K, Trieu J, Lee AK, Morandini F, Giner MP, Stiner J, Makarov MV, Garratt ES, Vasiloglou MF, Chanvillard L, Dalbram E, Ehrlich AM, Sanchez-Garcia JL, Canto C, Karagounis LG, Treebak JT, Migaud ME, Heshmat R, Razi F, Karnani N, Ostovar A, Farzadfar F, Tay SKH, Sanders MJ, Lillycrop KA, Godfrey KM, Nakagawa T, Moco S, Koopman R, Lynch GS, Sorrentino V, Feige JN. Membrez M, et al. Among authors: sanders mj. Nat Metab. 2024 Mar;6(3):433-447. doi: 10.1038/s42255-024-00997-x. Epub 2024 Mar 19. Nat Metab. 2024. PMID: 38504132 Free PMC article.
Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle.
Rhein P, Desjardins EM, Rong P, Ahwazi D, Bonhoure N, Stolte J, Santos MD, Ovens AJ, Ehrlich AM, Sanchez Garcia JL, Ouyang Q, Yabut JM, Kjolby M, Membrez M, Jessen N, Oakhill JS, Treebak JT, Maire P, Scott JW, Sanders MJ, Descombes P, Chen S, Steinberg GR, Sakamoto K. Rhein P, et al. Among authors: sanders mj. Mol Metab. 2021 Sep;51:101228. doi: 10.1016/j.molmet.2021.101228. Epub 2021 Mar 30. Mol Metab. 2021. PMID: 33798773 Free PMC article.
The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids.
Desjardins EM, Smith BK, Day EA, Ducommun S, Sanders MJ, Nederveen JP, Ford RJ, Pinkosky SL, Townsend LK, Gutgesell RM, Lu R, Sakamoto K, Steinberg GR. Desjardins EM, et al. Among authors: sanders mj. Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2119824119. doi: 10.1073/pnas.2119824119. Epub 2022 Nov 21. Proc Natl Acad Sci U S A. 2022. PMID: 36409897 Free PMC article.
Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis.
Neopane K, Kozlov N, Negoita F, Murray-Segal L, Brink R, Hoque A, Ovens AJ, Tjin G, McAloon LM, Yu D, Ling NXY, Sanders MJ, Oakhill JS, Scott JW, Steinberg GR, Loh K, Kemp BE, Sakamoto K, Galic S. Neopane K, et al. Among authors: sanders mj. Cell Rep. 2022 Dec 20;41(12):111862. doi: 10.1016/j.celrep.2022.111862. Cell Rep. 2022. PMID: 36543129 Free article.
AMP-activated protein kinase: nature's energy sensor.
Carling D, Mayer FV, Sanders MJ, Gamblin SJ. Carling D, et al. Among authors: sanders mj. Nat Chem Biol. 2011 Jul 18;7(8):512-8. doi: 10.1038/nchembio.610. Nat Chem Biol. 2011. PMID: 21769098 Review.
ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.
Mayer FV, Heath R, Underwood E, Sanders MJ, Carmena D, McCartney RR, Leiper FC, Xiao B, Jing C, Walker PA, Haire LF, Ogrodowicz R, Martin SR, Schmidt MC, Gamblin SJ, Carling D. Mayer FV, et al. Among authors: sanders mj. Cell Metab. 2011 Nov 2;14(5):707-14. doi: 10.1016/j.cmet.2011.09.009. Epub 2011 Oct 20. Cell Metab. 2011. PMID: 22019086 Free PMC article.
Structure of mammalian AMPK and its regulation by ADP.
Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing C, Walker PA, Eccleston JF, Haire LF, Saiu P, Howell SA, Aasland R, Martin SR, Carling D, Gamblin SJ. Xiao B, et al. Among authors: sanders mj. Nature. 2011 Apr 14;472(7342):230-3. doi: 10.1038/nature09932. Epub 2011 Mar 13. Nature. 2011. PMID: 21399626 Free PMC article.
Structural basis of AMPK regulation by small molecule activators.
Xiao B, Sanders MJ, Carmena D, Bright NJ, Haire LF, Underwood E, Patel BR, Heath RB, Walker PA, Hallen S, Giordanetto F, Martin SR, Carling D, Gamblin SJ. Xiao B, et al. Among authors: sanders mj. Nat Commun. 2013;4:3017. doi: 10.1038/ncomms4017. Nat Commun. 2013. PMID: 24352254 Free PMC article.
105 results