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Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity.
Lopes EA, Mestre R, Fontinha D, Legac J, Pei JV, Sanches-Vaz M, Mori M, Lehane AM, Rosenthal PJ, Prudêncio M, Santos MMM. Lopes EA, et al. Among authors: sanches vaz m. Eur J Med Chem. 2022 Jun 5;236:114324. doi: 10.1016/j.ejmech.2022.114324. Epub 2022 Mar 28. Eur J Med Chem. 2022. PMID: 35390711
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria.
Mayoka G, Njoroge M, Okombo J, Gibhard L, Sanches-Vaz M, Fontinha D, Birkholtz LM, Reader J, van der Watt M, Coetzer TL, Lauterbach S, Churchyard A, Bezuidenhout B, Egan TJ, Yeates C, Wittlin S, Prudêncio M, Chibale K. Mayoka G, et al. Among authors: sanches vaz m. J Med Chem. 2019 Jan 24;62(2):1022-1035. doi: 10.1021/acs.jmedchem.8b01769. Epub 2018 Dec 24. J Med Chem. 2019. PMID: 30562027
Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action.
Kumar M, Okombo J, Mambwe D, Taylor D, Lawrence N, Reader J, van der Watt M, Fontinha D, Sanches-Vaz M, Bezuidenhout BC, Lauterbach SB, Liebenberg D, Birkholtz LM, Coetzer TL, Prudêncio M, Egan TJ, Wittlin S, Chibale K. Kumar M, et al. Among authors: sanches vaz m. ACS Infect Dis. 2019 Feb 8;5(2):303-315. doi: 10.1021/acsinfecdis.8b00272. Epub 2019 Jan 7. ACS Infect Dis. 2019. PMID: 30525439
Excreted Trypanosoma brucei proteins inhibit Plasmodium hepatic infection.
Temporão A, Sanches-Vaz M, Luís R, Nunes-Cabaço H, Smith TK, Prudêncio M, Figueiredo LM. Temporão A, et al. Among authors: sanches vaz m. PLoS Negl Trop Dis. 2021 Oct 29;15(10):e0009912. doi: 10.1371/journal.pntd.0009912. eCollection 2021 Oct. PLoS Negl Trop Dis. 2021. PMID: 34714824 Free PMC article.
Trypanosoma brucei infection protects mice against malaria.
Sanches-Vaz M, Temporão A, Luis R, Nunes-Cabaço H, Mendes AM, Goellner S, Carvalho T, Figueiredo LM, Prudêncio M. Sanches-Vaz M, et al. PLoS Pathog. 2019 Nov 8;15(11):e1008145. doi: 10.1371/journal.ppat.1008145. eCollection 2019 Nov. PLoS Pathog. 2019. PMID: 31703103 Free PMC article.
12 results