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GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models.
Borner T, Geisler CE, Fortin SM, Cosgrove R, Alsina-Fernandez J, Dogra M, Doebley S, Sanchez-Navarro MJ, Leon RM, Gaisinsky J, White A, Bamezai A, Ghidewon MY, Grill HJ, Crist RC, Reiner BC, Ai M, Samms RJ, De Jonghe BC, Hayes MR. Borner T, et al. Among authors: samms rj. Diabetes. 2021 Nov;70(11):2545-2553. doi: 10.2337/db21-0459. Epub 2021 Aug 11. Diabetes. 2021. PMID: 34380697 Free PMC article.
The anti-obesity effect of FGF19 does not require UCP1-dependent thermogenesis.
Antonellis PJ, Droz BA, Cosgrove R, O'Farrell LS, Coskun T, Perfield JW 2nd, Bauer S, Wade M, Chouinard TE, Brozinick JT, Adams AC, Samms RJ. Antonellis PJ, et al. Among authors: samms rj. Mol Metab. 2019 Dec;30:131-139. doi: 10.1016/j.molmet.2019.09.006. Epub 2019 Sep 29. Mol Metab. 2019. PMID: 31767164 Free PMC article.
How May GIP Enhance the Therapeutic Efficacy of GLP-1?
Samms RJ, Coghlan MP, Sloop KW. Samms RJ, et al. Trends Endocrinol Metab. 2020 Jun;31(6):410-421. doi: 10.1016/j.tem.2020.02.006. Epub 2020 Mar 16. Trends Endocrinol Metab. 2020. PMID: 32396843 Free article. Review.
GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice.
Samms RJ, Christe ME, Collins KA, Pirro V, Droz BA, Holland AK, Friedrich JL, Wojnicki S, Konkol DL, Cosgrove R, Furber EPC, Ruan X, O'Farrell LS, Long AM, Dogra M, Willency JA, Lin Y, Ding L, Cheng CC, Cabrera O, Briere DA, Alsina-Fernandez J, Gimeno RE, Moyers JS, Coskun T, Coghlan MP, Sloop KW, Roell WC. Samms RJ, et al. J Clin Invest. 2021 Jun 15;131(12):e146353. doi: 10.1172/JCI146353. J Clin Invest. 2021. PMID: 34003802 Free PMC article.
GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior.
Samms RJ, Cosgrove R, Snider BM, Furber EC, Droz BA, Briere DA, Dunbar J, Dogra M, Alsina-Fernandez J, Borner T, De Jonghe BC, Hayes MR, Coskun T, Sloop KW, Emmerson PJ, Ai M. Samms RJ, et al. Diabetes. 2022 Jul 1;71(7):1410-1423. doi: 10.2337/db21-0848. Diabetes. 2022. PMID: 35499381 Free PMC article.
Is Glucagon Receptor Activation the Thermogenic Solution for Treating Obesity?
Conceição-Furber E, Coskun T, Sloop KW, Samms RJ. Conceição-Furber E, et al. Among authors: samms rj. Front Endocrinol (Lausanne). 2022 Apr 25;13:868037. doi: 10.3389/fendo.2022.868037. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35547006 Free PMC article. Review.
GIP receptor agonism blocks chemotherapy-induced nausea and vomiting.
Borner T, Reiner BC, Crist RC, Furst CD, Doebley SA, Halas JG, Ai M, Samms RJ, De Jonghe BC, Hayes MR. Borner T, et al. Among authors: samms rj. Mol Metab. 2023 Jul;73:101743. doi: 10.1016/j.molmet.2023.101743. Epub 2023 May 26. Mol Metab. 2023. PMID: 37245848 Free PMC article.
GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice.
Furber EC, Hyatt K, Collins K, Yu X, Droz BA, Holland A, Friedrich JL, Wojnicki S, Konkol DL, O'Farrell LS, Baker HE, Coskun T, Scherer PE, Kusminski CM, Christe ME, Sloop KW, Samms RJ. Furber EC, et al. Among authors: samms rj. Diabetes. 2024 Feb 1;73(2):292-305. doi: 10.2337/db23-0172. Diabetes. 2024. PMID: 37934926 Free PMC article.
30 results