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ATM deficiency confers specific therapeutic vulnerabilities in bladder cancer.
Zhou Y, Börcsök J, Adib E, Kamran SC, Neil AJ, Stawiski K, Freeman D, Stormoen DR, Sztupinszki Z, Samant A, Nassar A, Bekele RT, Hanlon T, Valentine H, Epstein I, Sharma B, Felt K, Abbosh P, Wu CL, Efstathiou JA, Miyamoto DT, Anderson W, Szallasi Z, Mouw KW. Zhou Y, et al. Among authors: samant a. Sci Adv. 2023 Nov 24;9(47):eadg2263. doi: 10.1126/sciadv.adg2263. Epub 2023 Nov 22. Sci Adv. 2023. PMID: 37992168 Free PMC article.
Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer.
Börcsök J, Sztupinszki Z, Bekele R, Gao SP, Diossy M, Samant AS, Dillon KM, Tisza V, Spisák S, Rusz O, Csabai I, Pappot H, Frazier ZJ, Konieczkowski DJ, Liu D, Vasani N, Rodrigues JA, Solit DB, Hoffman-Censits JH, Plimack ER, Rosenberg JE, Lazaro JB, Taplin ME, Iyer G, Brunak S, Lozsa R, Van Allen EM, Szüts D, Mouw KW, Szallasi Z. Börcsök J, et al. Among authors: samant as. Clin Cancer Res. 2021 Apr 1;27(7):2011-2022. doi: 10.1158/1078-0432.CCR-20-3316. Epub 2020 Nov 18. Clin Cancer Res. 2021. PMID: 33208343 Free PMC article.
RAF1 amplification drives a subset of bladder tumors and confers sensitivity to MAPK-directed therapeutics.
Bekele RT, Samant AS, Nassar AH, So J, Garcia EP, Curran CR, Hwang JH, Mayhew DL, Nag A, Thorner AR, Börcsök J, Sztupinszki Z, Pan CX, Bellmunt J, Kwiatkowski DJ, Sonpavde GP, Van Allen EM, Mouw KW. Bekele RT, et al. Among authors: samant as. J Clin Invest. 2021 Nov 15;131(22):e147849. doi: 10.1172/JCI147849. J Clin Invest. 2021. PMID: 34554931 Free PMC article.
Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions.
McCarver S, Hanna L, Samant A, Thompson AA, Seierstad M, Saha A, Wu D, Lord B, Sutton SW, Shah V, Milligan CM, Wennerholm M, Shelton J, Lebold TP, Shireman BT. McCarver S, et al. Among authors: samant a. ACS Med Chem Lett. 2024 Mar 7;15(4):486-492. doi: 10.1021/acsmedchemlett.3c00523. eCollection 2024 Apr 11. ACS Med Chem Lett. 2024. PMID: 38628796
A distinct class of hematopoietic stem cells develop from the human yellow bone marrow.
Nguyen TT, Loureiro ZY, Desai A, DeSouza T, Joyce S, Khair L, Samant A, Cirka H, Solivan-Rivera J, Ziegler R, Brehm M, Messina LM, Corvera S. Nguyen TT, et al. Among authors: samant a. bioRxiv [Preprint]. 2023 Aug 30:2023.08.29.555167. doi: 10.1101/2023.08.29.555167. bioRxiv. 2023. PMID: 37693594 Free PMC article. Preprint.
81 results