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Pharmacologic Normalization of Pancreatic Cancer-Associated Fibroblast Secretome Impairs Prometastatic Cross-Talk With Macrophages.
Samain R, Brunel A, Douché T, Fanjul M, Cassant-Sourdy S, Rochotte J, Cros J, Neuzillet C, Raffenne J, Duluc C, Perraud A, Nigri J, Gigoux V, Bieche I, Ponzo M, Carpentier G, Cascone I, Tomasini R, Schmid HA, Mathonnet M, Nicolle R, Bousquet MP, Martineau Y, Pyronnet S, Jean C, Bousquet C. Samain R, et al. Cell Mol Gastroenterol Hepatol. 2021;11(5):1405-1436. doi: 10.1016/j.jcmgh.2021.01.008. Epub 2021 Jan 20. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33482394 Free PMC article.
Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16.
Chalabi-Dchar M, Cassant-Sourdy S, Duluc C, Fanjul M, Lulka H, Samain R, Roche C, Breibach F, Delisle MB, Poupot M, Dufresne M, Shimaoka T, Yonehara S, Mathonnet M, Pyronnet S, Bousquet C. Chalabi-Dchar M, et al. Among authors: samain r. Gastroenterology. 2015 Jun;148(7):1452-65. doi: 10.1053/j.gastro.2015.02.009. Epub 2015 Feb 13. Gastroenterology. 2015. PMID: 25683115
Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance.
Duluc C, Moatassim-Billah S, Chalabi-Dchar M, Perraud A, Samain R, Breibach F, Gayral M, Cordelier P, Delisle MB, Bousquet-Dubouch MP, Tomasini R, Schmid H, Mathonnet M, Pyronnet S, Martineau Y, Bousquet C. Duluc C, et al. Among authors: samain r. EMBO Mol Med. 2015 Jun;7(6):735-53. doi: 10.15252/emmm.201404346. EMBO Mol Med. 2015. PMID: 25834145 Free PMC article.
Anti-metastatic potential of somatostatin analog SOM230: Indirect pharmacological targeting of pancreatic cancer-associated fibroblasts.
Moatassim-Billah S, Duluc C, Samain R, Jean C, Perraud A, Decaup E, Cassant-Sourdy S, Bakri Y, Selves J, Schmid H, Martineau Y, Mathonnet M, Pyronnet S, Bousquet C. Moatassim-Billah S, et al. Among authors: samain r. Oncotarget. 2016 Jul 5;7(27):41584-41598. doi: 10.18632/oncotarget.9296. Oncotarget. 2016. PMID: 27177087 Free PMC article.
Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer.
Goehrig D, Nigri J, Samain R, Wu Z, Cappello P, Gabiane G, Zhang X, Zhao Y, Kim IS, Chanal M, Curto R, Hervieu V, de La Fouchardière C, Novelli F, Milani P, Tomasini R, Bousquet C, Bertolino P, Hennino A. Goehrig D, et al. Among authors: samain r. Gut. 2019 Apr;68(4):693-707. doi: 10.1136/gutjnl-2018-317570. Epub 2018 Nov 10. Gut. 2019. PMID: 30415234 Free PMC article.
eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.
Müller D, Shin S, Goullet de Rugy T, Samain R, Baer R, Strehaiano M, Masvidal-Sanz L, Guillermet-Guibert J, Jean C, Tsukumo Y, Sonenberg N, Marion F, Guilbaud N, Hoffmann JS, Larsson O, Bousquet C, Pyronnet S, Martineau Y. Müller D, et al. Among authors: samain r. JCI Insight. 2019 Nov 1;4(21):e121951. doi: 10.1172/jci.insight.121951. JCI Insight. 2019. PMID: 31672935 Free PMC article.
FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer.
Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant-Sourdy S, Rochotte J, Brunel A, Schlaepfer D, Cros J, Neuzillet C, Strehaiano M, Alard A, Tomasini R, Rajeeve V, Perraud A, Mathonnet M, Pearce OM, Martineau Y, Pyronnet S, Bousquet C, Jean C. Zaghdoudi S, et al. Among authors: samain r. EMBO Mol Med. 2020 Nov 6;12(11):e12010. doi: 10.15252/emmm.202012010. Epub 2020 Oct 7. EMBO Mol Med. 2020. PMID: 33025708 Free PMC article.
Periostin- and podoplanin-positive cancer-associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma.
Neuzillet C, Nicolle R, Raffenne J, Tijeras-Raballand A, Brunel A, Astorgues-Xerri L, Vacher S, Arbateraz F, Fanjul M, Hilmi M, Samain R, Klein C, Perraud A, Rebours V, Mathonnet M, Bièche I, Kocher H, Cros J, Bousquet C. Neuzillet C, et al. Among authors: samain r. J Pathol. 2022 Dec;258(4):408-425. doi: 10.1002/path.6011. Epub 2022 Oct 21. J Pathol. 2022. PMID: 36102377 Free PMC article.
Rho GTPase signaling in cancer progression and dissemination.
Crosas-Molist E, Samain R, Kohlhammer L, Orgaz JL, George SL, Maiques O, Barcelo J, Sanz-Moreno V. Crosas-Molist E, et al. Among authors: samain r. Physiol Rev. 2022 Jan 1;102(1):455-510. doi: 10.1152/physrev.00045.2020. Epub 2021 Sep 20. Physiol Rev. 2022. PMID: 34541899 Free article. Review.
13 results