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Challenges in IBD Research: Preclinical Human IBD Mechanisms.
Pizarro TT, Stappenbeck TS, Rieder F, Rosen MJ, Colombel JF, Donowitz M, Towne J, Mazmanian SK, Faith JJ, Hodin RA, Garrett WS, Fichera A, Poritz LS, Cortes CJ, Shtraizent N, Honig G, Snapper SB, Hurtado-Lorenzo A, Salzman NH, Chang EB. Pizarro TT, et al. Among authors: salzman nh. Inflamm Bowel Dis. 2019 May 16;25(Suppl 2):S5-S12. doi: 10.1093/ibd/izz075. Inflamm Bowel Dis. 2019. PMID: 31095706 Review.
Negative interactions with the microbiota: IBD.
Salzman NH, Bevins CL. Salzman NH, et al. Adv Exp Med Biol. 2008;635:67-78. doi: 10.1007/978-0-387-09550-9_6. Adv Exp Med Biol. 2008. PMID: 18841704 Review.
Paneth cell defects in Crohn's disease patients promote dysbiosis.
Liu TC, Gurram B, Baldridge MT, Head R, Lam V, Luo C, Cao Y, Simpson P, Hayward M, Holtz ML, Bousounis P, Noe J, Lerner D, Cabrera J, Biank V, Stephens M, Huttenhower C, McGovern DP, Xavier RJ, Stappenbeck TS, Salzman NH. Liu TC, et al. Among authors: salzman nh. JCI Insight. 2016 Jun 2;1(8):e86907. doi: 10.1172/jci.insight.86907. JCI Insight. 2016. PMID: 27699268 Free PMC article.
A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells.
Chang YL, Rossetti M, Vlamakis H, Casero D, Sunga G, Harre N, Miller S, Humphries R, Stappenbeck T, Simpson KW, Sartor RB, Wu G, Lewis J, Bushman F, McGovern DPB, Salzman N, Borneman J, Xavier R, Huttenhower C, Braun J. Chang YL, et al. Mucosal Immunol. 2019 Mar;12(2):457-467. doi: 10.1038/s41385-018-0022-7. Epub 2018 Apr 25. Mucosal Immunol. 2019. PMID: 29695840 Free PMC article.
IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy.
Schmitt EG, Haribhai D, Williams JB, Aggarwal P, Jia S, Charbonnier LM, Yan K, Lorier R, Turner A, Ziegelbauer J, Georgiev P, Simpson P, Salzman NH, Hessner MJ, Broeckel U, Chatila TA, Williams CB. Schmitt EG, et al. Among authors: salzman nh. J Immunol. 2012 Dec 15;189(12):5638-48. doi: 10.4049/jimmunol.1200936. Epub 2012 Nov 2. J Immunol. 2012. PMID: 23125413 Free PMC article.
87 results