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The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.
Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J. Brumatti G, et al. Among authors: salvesen g. Sci Transl Med. 2016 May 18;8(339):339ra69. doi: 10.1126/scitranslmed.aad3099. Sci Transl Med. 2016. PMID: 27194727
Caspase selective reagents for diagnosing apoptotic mechanisms.
Poreba M, Groborz K, Navarro M, Snipas SJ, Drag M, Salvesen GS. Poreba M, et al. Cell Death Differ. 2019 Feb;26(2):229-244. doi: 10.1038/s41418-018-0110-y. Epub 2018 May 10. Cell Death Differ. 2019. PMID: 29748600 Free PMC article.
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia.
Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC. Krajewski S, et al. Among authors: salvesen gs. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5752-7. doi: 10.1073/pnas.96.10.5752. Proc Natl Acad Sci U S A. 1999. PMID: 10318956 Free PMC article.
Caspases and apoptosis.
Salvesen GS. Salvesen GS. Essays Biochem. 2002;38:9-19. doi: 10.1042/bse0380009. Essays Biochem. 2002. PMID: 12463158 Review.
Mechanisms of caspase activation.
Boatright KM, Salvesen GS. Boatright KM, et al. Curr Opin Cell Biol. 2003 Dec;15(6):725-31. doi: 10.1016/j.ceb.2003.10.009. Curr Opin Cell Biol. 2003. PMID: 14644197 Review.
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
Schimmer AD, Welsh K, Pinilla C, Wang Z, Krajewska M, Bonneau MJ, Pedersen IM, Kitada S, Scott FL, Bailly-Maitre B, Glinsky G, Scudiero D, Sausville E, Salvesen G, Nefzi A, Ostresh JM, Houghten RA, Reed JC. Schimmer AD, et al. Among authors: salvesen g. Cancer Cell. 2004 Jan;5(1):25-35. doi: 10.1016/s1535-6108(03)00332-5. Cancer Cell. 2004. PMID: 14749124 Free article.
323 results