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N-(1'-naphthyl)-3,4,5-trimethoxybenzohydrazide as microtubule destabilizer: Synthesis, cytotoxicity, inhibition of cell migration and in vivo activity against acute lymphoblastic leukemia.
Salum LB, Mascarello A, Canevarolo RR, Altei WF, Laranjeira AB, Neuenfeldt PD, Stumpf TR, Chiaradia-Delatorre LD, Vollmer LL, Daghestani HN, de Souza Melo CP, Silveira AB, Leal PC, Frederico MJ, do Nascimento LF, Santos AR, Andricopulo AD, Day BW, Yunes RA, Vogt A, Yunes JA, Nunes RJ. Salum LB, et al. Eur J Med Chem. 2015;96:504-18. doi: 10.1016/j.ejmech.2015.02.041. Epub 2015 Feb 23. Eur J Med Chem. 2015. PMID: 25951294
Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.
Salum LB, Altei WF, Chiaradia LD, Cordeiro MN, Canevarolo RR, Melo CP, Winter E, Mattei B, Daghestani HN, Santos-Silva MC, Creczynski-Pasa TB, Yunes RA, Yunes JA, Andricopulo AD, Day BW, Nunes RJ, Vogt A. Salum LB, et al. Eur J Med Chem. 2013 May;63:501-10. doi: 10.1016/j.ejmech.2013.02.037. Epub 2013 Mar 6. Eur J Med Chem. 2013. PMID: 23524161 Free PMC article.
Fragment-based QSAR: perspectives in drug design.
Salum LB, Andricopulo AD. Salum LB, et al. Mol Divers. 2009 Aug;13(3):277-85. doi: 10.1007/s11030-009-9112-5. Epub 2009 Jan 31. Mol Divers. 2009. PMID: 19184499 Review.
Structure-based drug design strategies in medicinal chemistry.
Andricopulo AD, Salum LB, Abraham DJ. Andricopulo AD, et al. Among authors: salum lb. Curr Top Med Chem. 2009;9(9):771-90. doi: 10.2174/156802609789207127. Curr Top Med Chem. 2009. PMID: 19754394 Free article. Review.
N⁴-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: cytotoxicity against human tumor cells, structure-activity relationship studies and investigation on the mechanism of action.
Soares MA, Lessa JA, Mendes IC, Da Silva JG, Dos Santos RG, Salum LB, Daghestani H, Andricopulo AD, Day BW, Vogt A, Pesquero JL, Rocha WR, Beraldo H. Soares MA, et al. Among authors: salum lb. Bioorg Med Chem. 2012 Jun 1;20(11):3396-409. doi: 10.1016/j.bmc.2012.04.027. Epub 2012 Apr 19. Bioorg Med Chem. 2012. PMID: 22564383 Free article.
Fragment-based QSAR strategies in drug design.
Salum LB, Andricopulo AD. Salum LB, et al. Expert Opin Drug Discov. 2010 May;5(5):405-12. doi: 10.1517/17460441003782277. Epub 2010 Mar 31. Expert Opin Drug Discov. 2010. PMID: 22823126
16 results