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Discovery and structure-activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors.
Lyons A, Kirkham J, Blades K, Orr D, Dauncey E, Smith O, Dick E, Walker R, Matthews T, Bunt A, Finlayson J, Morrison I, Savage VJ, Moyo E, Butler HS, Newman R, Ooi N, Smith A, Charrier C, Ratcliffe AJ, Stokes NR, Best S, Salisbury AM, Craighead M, Cooper IR. Lyons A, et al. Among authors: salisbury am. Bioorg Med Chem Lett. 2022 Jun 1;65:128648. doi: 10.1016/j.bmcl.2022.128648. Epub 2022 Feb 26. Bioorg Med Chem Lett. 2022. PMID: 35231579
Biological profiling of novel tricyclic inhibitors of bacterial DNA gyrase and topoisomerase IV.
Savage VJ, Charrier C, Salisbury AM, Moyo E, Forward H, Chaffer-Malam N, Metzger R, Huxley A, Kirk R, Uosis-Martin M, Noonan G, Mohmed S, Best SA, Ratcliffe AJ, Stokes NR. Savage VJ, et al. Among authors: salisbury am. J Antimicrob Chemother. 2016 Jul;71(7):1905-13. doi: 10.1093/jac/dkw061. Epub 2016 Mar 30. J Antimicrob Chemother. 2016. PMID: 27032669
Efficacy of a Novel Tricyclic Topoisomerase Inhibitor in a Murine Model of Neisseria gonorrhoeae Infection.
Savage VJ, Charrier C, Salisbury AM, Box H, Chaffer-Malam N, Huxley A, Kirk R, Noonan GM, Mohmed S, Craighead MW, Ratcliffe AJ, Best SA, Stokes NR. Savage VJ, et al. Among authors: salisbury am. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5592-4. doi: 10.1128/AAC.00913-16. Print 2016 Sep. Antimicrob Agents Chemother. 2016. PMID: 27324777 Free PMC article.
Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.
Cooper IR, McCarroll AJ, McGarry D, Kirkham J, Pichowicz M, Walker R, Warrilow C, Salisbury AM, Savage VJ, Moyo E, Forward H, Cheung J, Metzger R, Gault Z, Nelson G, Hughes D, Cao S, Maclean J, Charrier C, Craighead M, Best S, Stokes NR, Ratcliffe AJ. Cooper IR, et al. Among authors: salisbury am. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4179-83. doi: 10.1016/j.bmcl.2016.07.061. Epub 2016 Jul 28. Bioorg Med Chem Lett. 2016. PMID: 27499455 Free article.
Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria.
Charrier C, Salisbury AM, Savage VJ, Duffy T, Moyo E, Chaffer-Malam N, Ooi N, Newman R, Cheung J, Metzger R, McGarry D, Pichowicz M, Sigerson R, Cooper IR, Nelson G, Butler HS, Craighead M, Ratcliffe AJ, Best SA, Stokes NR. Charrier C, et al. Among authors: salisbury am. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02100-16. doi: 10.1128/AAC.02100-16. Print 2017 May. Antimicrob Agents Chemother. 2017. PMID: 28223393 Free PMC article.
Design, synthesis and antibacterial properties of pyrimido[4,5-b]indol-8-amine inhibitors of DNA gyrase.
McGarry DH, Cooper IR, Walker R, Warrilow CE, Pichowicz M, Ratcliffe AJ, Salisbury AM, Savage VJ, Moyo E, Maclean J, Smith A, Charrier C, Stokes NR, Lindsay DM, Kerr WJ. McGarry DH, et al. Among authors: salisbury am. Bioorg Med Chem Lett. 2018 Sep 15;28(17):2998-3003. doi: 10.1016/j.bmcl.2018.05.049. Epub 2018 May 26. Bioorg Med Chem Lett. 2018. PMID: 30122228 Free article.
Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase.
Henderson SR, Stevenson CEM, Malone B, Zholnerovych Y, Mitchenall LA, Pichowicz M, McGarry DH, Cooper IR, Charrier C, Salisbury AM, Lawson DM, Maxwell A. Henderson SR, et al. Among authors: salisbury am. J Antimicrob Chemother. 2020 Oct 1;75(10):2835-2842. doi: 10.1093/jac/dkaa286. J Antimicrob Chemother. 2020. PMID: 32728686 Free PMC article.
35 results