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One or two dose regimen of the SARS-CoV-2 synthetic DNA vaccine INO-4800 protects against respiratory tract disease burden in nonhuman primate challenge model.
Gooch KE, Smith TRF, Salguero FJ, Fotheringham SA, Watson RJ, Dennis MJ, Handley A, Humphries HE, Longet S, Tipton T, Sarfas C, Sibley L, Slack GS, Rayner E, Ryan KA, Schultheis K, Ramos SJ, White A, Charlton S, Sharpe SA, Gleeson F, Humeau LM, Hall Y, Broderick KE, Carroll MW. Gooch KE, et al. Among authors: salguero fj. Vaccine. 2021 Aug 9;39(34):4885-4894. doi: 10.1016/j.vaccine.2021.06.057. Epub 2021 Jun 23. Vaccine. 2021. PMID: 34253420 Free PMC article.
Animal models for COVID-19.
Muñoz-Fontela C, Dowling WE, Funnell SGP, Gsell PS, Riveros-Balta AX, Albrecht RA, Andersen H, Baric RS, Carroll MW, Cavaleri M, Qin C, Crozier I, Dallmeier K, de Waal L, de Wit E, Delang L, Dohm E, Duprex WP, Falzarano D, Finch CL, Frieman MB, Graham BS, Gralinski LE, Guilfoyle K, Haagmans BL, Hamilton GA, Hartman AL, Herfst S, Kaptein SJF, Klimstra WB, Knezevic I, Krause PR, Kuhn JH, Le Grand R, Lewis MG, Liu WC, Maisonnasse P, McElroy AK, Munster V, Oreshkova N, Rasmussen AL, Rocha-Pereira J, Rockx B, Rodríguez E, Rogers TF, Salguero FJ, Schotsaert M, Stittelaar KJ, Thibaut HJ, Tseng CT, Vergara-Alert J, Beer M, Brasel T, Chan JFW, García-Sastre A, Neyts J, Perlman S, Reed DS, Richt JA, Roy CJ, Segalés J, Vasan SS, Henao-Restrepo AM, Barouch DH. Muñoz-Fontela C, et al. Among authors: salguero fj. Nature. 2020 Oct;586(7830):509-515. doi: 10.1038/s41586-020-2787-6. Epub 2020 Sep 23. Nature. 2020. PMID: 32967005 Free PMC article. Review.
MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies.
White AD, Sibley L, Sarfas C, Morrison A, Gullick J, Clark S, Gleeson F, McIntyre A, Arlehamn CL, Sette A, Salguero FJ, Rayner E, Rodriguez E, Puentes E, Laddy D, Williams A, Dennis M, Martin C, Sharpe S. White AD, et al. Among authors: salguero fj. NPJ Vaccines. 2021 Jan 4;6(1):4. doi: 10.1038/s41541-020-00262-8. NPJ Vaccines. 2021. PMID: 33397991 Free PMC article.
Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity.
Ryan KA, Bewley KR, Fotheringham SA, Slack GS, Brown P, Hall Y, Wand NI, Marriott AC, Cavell BE, Tree JA, Allen L, Aram MJ, Bean TJ, Brunt E, Buttigieg KR, Carter DP, Cobb R, Coombes NS, Findlay-Wilson SJ, Godwin KJ, Gooch KE, Gouriet J, Halkerston R, Harris DJ, Hender TH, Humphries HE, Hunter L, Ho CMK, Kennard CL, Leung S, Longet S, Ngabo D, Osman KL, Paterson J, Penn EJ, Pullan ST, Rayner E, Skinner O, Steeds K, Taylor I, Tipton T, Thomas S, Turner C, Watson RJ, Wiblin NR, Charlton S, Hallis B, Hiscox JA, Funnell S, Dennis MJ, Whittaker CJ, Catton MG, Druce J, Salguero FJ, Carroll MW. Ryan KA, et al. Among authors: salguero fj. Nat Commun. 2021 Jan 4;12(1):81. doi: 10.1038/s41467-020-20439-y. Nat Commun. 2021. PMID: 33398055 Free PMC article.
Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19.
Salguero FJ, White AD, Slack GS, Fotheringham SA, Bewley KR, Gooch KE, Longet S, Humphries HE, Watson RJ, Hunter L, Ryan KA, Hall Y, Sibley L, Sarfas C, Allen L, Aram M, Brunt E, Brown P, Buttigieg KR, Cavell BE, Cobb R, Coombes NS, Darby A, Daykin-Pont O, Elmore MJ, Garcia-Dorival I, Gkolfinos K, Godwin KJ, Gouriet J, Halkerston R, Harris DJ, Hender T, Ho CMK, Kennard CL, Knott D, Leung S, Lucas V, Mabbutt A, Morrison AL, Nelson C, Ngabo D, Paterson J, Penn EJ, Pullan S, Taylor I, Tipton T, Thomas S, Tree JA, Turner C, Vamos E, Wand N, Wiblin NR, Charlton S, Dong X, Hallis B, Pearson G, Rayner EL, Nicholson AG, Funnell SG, Hiscox JA, Dennis MJ, Gleeson FV, Sharpe S, Carroll MW. Salguero FJ, et al. Nat Commun. 2021 Feb 24;12(1):1260. doi: 10.1038/s41467-021-21389-9. Nat Commun. 2021. PMID: 33627662 Free PMC article.
ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models.
Lambe T, Spencer AJ, Thomas KM, Gooch KE, Thomas S, White AD, Humphries HE, Wright D, Belij-Rammerstorfer S, Thakur N, Conceicao C, Watson R, Alden L, Allen L, Aram M, Bewley KR, Brunt E, Brown P, Cavell BE, Cobb R, Fotheringham SA, Gilbride C, Harris DJ, Ho CMK, Hunter L, Kennard CL, Leung S, Lucas V, Ngabo D, Ryan KA, Sharpe H, Sarfas C, Sibley L, Slack GS, Ulaszewska M, Wand N, Wiblin NR, Gleeson FV, Bailey D, Sharpe S, Charlton S, Salguero FJ, Carroll MW, Gilbert SC. Lambe T, et al. Among authors: salguero fj. Commun Biol. 2021 Jul 26;4(1):915. doi: 10.1038/s42003-021-02443-0. Commun Biol. 2021. PMID: 34312487 Free PMC article.
Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model.
Bessière P, Wasniewski M, Picard-Meyer E, Servat A, Figueroa T, Foret-Lucas C, Coggon A, Lesellier S, Boué F, Cebron N, Gausserès B, Trumel C, Foucras G, Salguero FJ, Monchatre-Leroy E, Volmer R. Bessière P, et al. Among authors: salguero fj. PLoS Pathog. 2021 Aug 9;17(8):e1009427. doi: 10.1371/journal.ppat.1009427. eCollection 2021 Aug. PLoS Pathog. 2021. PMID: 34370799 Free PMC article.
Immunological and pathological outcomes of SARS-CoV-2 challenge following formalin-inactivated vaccine in ferrets and rhesus macaques.
Bewley KR, Gooch K, Thomas KM, Longet S, Wiblin N, Hunter L, Chan K, Brown P, Russell RA, Ho C, Slack G, Humphries HE, Alden L, Allen L, Aram M, Baker N, Brunt E, Cobb R, Fotheringham S, Harris D, Kennard C, Leung S, Ryan K, Tolley H, Wand N, White A, Sibley L, Sarfas C, Pearson G, Rayner E, Xue X, Lambe T, Charlton S, Gilbert S, Sattentau QJ, Gleeson F, Hall Y, Funnell S, Sharpe S, Salguero FJ, Gorringe A, Carroll M. Bewley KR, et al. Among authors: salguero fj. Sci Adv. 2021 Sep 10;7(37):eabg7996. doi: 10.1126/sciadv.abg7996. Epub 2021 Sep 10. Sci Adv. 2021. PMID: 34516768 Free PMC article.
A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19.
Huo J, Mikolajek H, Le Bas A, Clark JJ, Sharma P, Kipar A, Dormon J, Norman C, Weckener M, Clare DK, Harrison PJ, Tree JA, Buttigieg KR, Salguero FJ, Watson R, Knott D, Carnell O, Ngabo D, Elmore MJ, Fotheringham S, Harding A, Moynié L, Ward PN, Dumoux M, Prince T, Hall Y, Hiscox JA, Owen A, James W, Carroll MW, Stewart JP, Naismith JH, Owens RJ. Huo J, et al. Among authors: salguero fj. Nat Commun. 2021 Sep 22;12(1):5469. doi: 10.1038/s41467-021-25480-z. Nat Commun. 2021. PMID: 34552091 Free PMC article.
205 results