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Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease.
Hernández-Alvarez MI, Sebastián D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, Plana N, Veiga SR, Hernández V, Vasconcelos N, Peddinti G, Adrover A, Jové M, Pamplona R, Gordaliza-Alaguero I, Calvo E, Cabré N, Castro R, Kuzmanic A, Boutant M, Sala D, Hyotylainen T, Orešič M, Fort J, Errasti-Murugarren E, Rodrígues CMP, Orozco M, Joven J, Cantó C, Palacin M, Fernández-Veledo S, Vendrell J, Zorzano A. Hernández-Alvarez MI, et al. Among authors: sala d. Cell. 2019 May 2;177(4):881-895.e17. doi: 10.1016/j.cell.2019.04.010. Cell. 2019. PMID: 31051106 Free article.
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis.
Sebastián D, Hernández-Alvarez MI, Segalés J, Sorianello E, Muñoz JP, Sala D, Waget A, Liesa M, Paz JC, Gopalacharyulu P, Orešič M, Pich S, Burcelin R, Palacín M, Zorzano A. Sebastián D, et al. Among authors: sala d. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5523-8. doi: 10.1073/pnas.1108220109. Epub 2012 Mar 16. Proc Natl Acad Sci U S A. 2012. PMID: 22427360 Free PMC article.
A form of mitofusin 2 (Mfn2) lacking the transmembrane domains and the COOH-terminal end stimulates metabolism in muscle and liver cells.
Segalés J, Paz JC, Hernández-Alvarez MI, Sala D, Muñoz JP, Noguera E, Pich S, Palacín M, Enríquez JA, Zorzano A. Segalés J, et al. Among authors: sala d. Am J Physiol Endocrinol Metab. 2013 Nov 15;305(10):E1208-21. doi: 10.1152/ajpendo.00546.2012. Epub 2013 Aug 13. Am J Physiol Endocrinol Metab. 2013. PMID: 23941871 Free article.
Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes.
Sala D, Ivanova S, Plana N, Ribas V, Duran J, Bach D, Turkseven S, Laville M, Vidal H, Karczewska-Kupczewska M, Kowalska I, Straczkowski M, Testar X, Palacín M, Sandri M, Serrano AL, Zorzano A. Sala D, et al. J Clin Invest. 2014 May;124(5):1914-27. doi: 10.1172/JCI72327. Epub 2014 Apr 8. J Clin Invest. 2014. PMID: 24713655 Free PMC article.
Fatty acid transport protein 1 (FATP1) localizes in mitochondria in mouse skeletal muscle and regulates lipid and ketone body disposal.
Guitart M, Osorio-Conles O, Pentinat T, Cebrià J, García-Villoria J, Sala D, Sebastián D, Zorzano A, Ribes A, Jiménez-Chillarón JC, García-Martínez C, Gómez-Foix AM. Guitart M, et al. Among authors: sala d. PLoS One. 2014 May 23;9(5):e98109. doi: 10.1371/journal.pone.0098109. eCollection 2014. PLoS One. 2014. PMID: 24858472 Free PMC article.
Is TP53INP2 a critical regulator of muscle mass?
Sala D, Zorzano A. Sala D, et al. Curr Opin Clin Nutr Metab Care. 2015 May;18(3):234-9. doi: 10.1097/MCO.0000000000000163. Curr Opin Clin Nutr Metab Care. 2015. PMID: 25769060 Review.
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway.
Sebastián D, Sorianello E, Segalés J, Irazoki A, Ruiz-Bonilla V, Sala D, Planet E, Berenguer-Llergo A, Muñoz JP, Sánchez-Feutrie M, Plana N, Hernández-Álvarez MI, Serrano AL, Palacín M, Zorzano A. Sebastián D, et al. Among authors: sala d. EMBO J. 2016 Aug 1;35(15):1677-93. doi: 10.15252/embj.201593084. Epub 2016 Jun 22. EMBO J. 2016. PMID: 27334614 Free PMC article.
226 results