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Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis.
Luukkonen PK, Sakuma I, Gaspar RC, Mooring M, Nasiri A, Kahn M, Zhang XM, Zhang D, Sammalkorpi H, Penttilä AK, Orho-Melander M, Arola J, Juuti A, Zhang X, Yimlamai D, Yki-Järvinen H, Petersen KF, Shulman GI. Luukkonen PK, et al. Among authors: sakuma i. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2217543120. doi: 10.1073/pnas.2217543120. Epub 2023 Jan 20. Proc Natl Acad Sci U S A. 2023. PMID: 36669104 Free PMC article.
Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice.
Gaspar RC, Lyu K, Hubbard BT, Leitner BP, Luukkonen PK, Hirabara SM, Sakuma I, Nasiri A, Zhang D, Kahn M, Cline GW, Pauli JR, Perry RJ, Petersen KF, Shulman GI. Gaspar RC, et al. Among authors: sakuma i. Diabetologia. 2023 Mar;66(3):567-578. doi: 10.1007/s00125-022-05838-8. Epub 2022 Dec 1. Diabetologia. 2023. PMID: 36456864
O-linked N-acetylglucosamine modification is essential for physiological adipose expansion induced by high-fat feeding.
Nakamoto A, Ohashi N, Sugawara L, Morino K, Ida S, Perry RJ, Sakuma I, Yanagimachi T, Fujita Y, Ugi S, Kume S, Shulman GI, Maegawa H. Nakamoto A, et al. Among authors: sakuma i. Am J Physiol Endocrinol Metab. 2023 Jul 1;325(1):E46-E61. doi: 10.1152/ajpendo.00263.2022. Epub 2023 May 24. Am J Physiol Endocrinol Metab. 2023. PMID: 37224467
Fatty Acid Esterification as a NASH Therapeutic Target.
Sakuma I, Vatner DF. Sakuma I, et al. Cell Mol Gastroenterol Hepatol. 2024;17(2):311-312. doi: 10.1016/j.jcmgh.2023.10.011. Epub 2023 Nov 17. Cell Mol Gastroenterol Hepatol. 2024. PMID: 37984466 Free PMC article. No abstract available.
Effect of Luseogliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, and Dipeptidyl-Peptidase 4 Inhibitors on the Quality-of-Life and Treatment Satisfaction of Patients With Type 2 Diabetes Mellitus: A Subanalysis of a Multicenter, Open-Label, Randomized-Controlled Trial (J-SELECT Study).
Fukuda M, Sakuma I, Wakasa Y, Funayama H, Kondo A, Itabashi N, Maruyama Y, Kamiyama T, Utsunomiya Y, Yamauchi A, Yoshii H, Yamada H, Mochizuki K, Sugawara M; J-SELECT study investigators. Fukuda M, et al. Among authors: sakuma i. Diabetes Ther. 2024 Apr 24. doi: 10.1007/s13300-024-01575-w. Online ahead of print. Diabetes Ther. 2024. PMID: 38653904
Switching from Conventional Fibrates to Pemafibrate Has Beneficial Effects on the Renal Function of Diabetic Subjects with Chronic Kidney Disease.
Izumihara R, Nomoto H, Kito K, Yamauchi Y, Omori K, Shibayama Y, Yanagiya S, Miya A, Kameda H, Cho KY, Nagai S, Sakuma I, Nakamura A, Atsumi T; PARM-T2D Study Group. Izumihara R, et al. Among authors: sakuma i. Diabetes Metab J. 2024 Feb 29. doi: 10.4093/dmj.2023.0370. Online ahead of print. Diabetes Metab J. 2024. PMID: 38419467 Free article.
DAPagliflozin for the attenuation of albuminuria in Patients with hEaRt failure and type 2 diabetes (DAPPER study): a multicentre, randomised, open-label, parallel-group, standard treatment-controlled trial.
Yoshihara F, Imazu M, Sakuma I, Hiroi Y, Hara H, Okazaki O, Ishiguro C, Izumi C, Noguchi T, Shiraiwa T, Nishioka N, Fujii K, Iwakura K, Tomonaga O, Kobayashi K, Takihata M, Yumoto K, Takase H, Himi T, Shimizu I, Murakami T, Wagatsuma K, Sato K, Hiramatsu T, Akabame S, Hata S, Asakura M, Kawabata T, Omae K, Ito S, Kitakaze M; DAPPER Investigators. Yoshihara F, et al. Among authors: sakuma i. EClinicalMedicine. 2023 Nov 27;66:102334. doi: 10.1016/j.eclinm.2023.102334. eCollection 2023 Dec. EClinicalMedicine. 2023. PMID: 38192595 Free PMC article.
491 results