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Unified framework for patient-derived, tumor-organoid-based predictive testing of standard-of-care therapies in metastatic colorectal cancer.
Tan T, Mouradov D, Lee M, Gard G, Hirokawa Y, Li S, Lin C, Li F, Luo H, Wu K, Palmieri M, Leong E, Clarke J, Sakthianandeswaren A, Brasier H, Tie J, Tebbutt NC, Jalali A, Wong R, Burgess AW, Gibbs P, Sieber OM. Tan T, et al. Among authors: sakthianandeswaren a. Cell Rep Med. 2023 Dec 19;4(12):101335. doi: 10.1016/j.xcrm.2023.101335. Cell Rep Med. 2023. PMID: 38118423 Free PMC article.
Oncomicrobial Community Profiling Identifies Clinicomolecular and Prognostic Subtypes of Colorectal Cancer.
Mouradov D, Greenfield P, Li S, In EJ, Storey C, Sakthianandeswaren A, Georgeson P, Buchanan DD, Ward RL, Hawkins NJ, Skinner I, Jones IT, Gibbs P, Ma C, Liew YJ, Fung KYC, Sieber OM. Mouradov D, et al. Among authors: sakthianandeswaren a. Gastroenterology. 2023 Jul;165(1):104-120. doi: 10.1053/j.gastro.2023.03.205. Epub 2023 Mar 16. Gastroenterology. 2023. PMID: 36933623
PI3Kα Translocation Mediates Nuclear PtdIns(3,4,5)P3 Effector Signaling in Colorectal Cancer.
Palmieri M, Catimel B, Mouradov D, Sakthianandeswaren A, Kapp E, Ang CS, Williamson NA, Nowell CJ, Christie M, Desai J, Gibbs P, Burgess AW, Sieber OM. Palmieri M, et al. Among authors: sakthianandeswaren a. Mol Cell Proteomics. 2023 Apr;22(4):100529. doi: 10.1016/j.mcpro.2023.100529. Epub 2023 Mar 16. Mol Cell Proteomics. 2023. PMID: 36931626 Free PMC article.
CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation.
Chüeh AC, Advani G, Foroutan M, Smith J, Ng N, Nandurkar H, Lio DS, Zhu HJ, Chong YP, Verkade H, Fujita DJ, Bjorge J, Basheer F, Lim JP, Luk I, Dhillon A, Sakthianandeswaren A, Mouradov D, Sieber O, Hollande F, Mariadason JM, Cheng HC. Chüeh AC, et al. Among authors: sakthianandeswaren a. Oncogene. 2021 Apr;40(17):3015-3029. doi: 10.1038/s41388-021-01755-z. Epub 2021 Mar 25. Oncogene. 2021. PMID: 33767439
Defining the susceptibility of colorectal cancers to BH3-mimetic compounds.
Luo MJ, Palmieri M, Riffkin CD, Sakthianandeswaren A, Djajawi TM, Hirokawa Y, Shuttleworth V, Segal DH, White CA, Nhu D, Lessene G, Lee M, Gibbs P, Huang DCS, Sieber OM, Gong JN. Luo MJ, et al. Among authors: sakthianandeswaren a. Cell Death Dis. 2020 Sep 10;11(9):735. doi: 10.1038/s41419-020-02815-0. Cell Death Dis. 2020. PMID: 32913182 Free PMC article.
Tumour infiltrating lymphocyte status is superior to histological grade, DNA mismatch repair and BRAF mutation for prognosis of colorectal adenocarcinomas with mucinous differentiation.
Williams DS, Mouradov D, Newman MR, Amini E, Nickless DK, Fang CG, Palmieri M, Sakthianandeswaren A, Li S, Ward RL, Hawkins NJ, Skinner I, Jones I, Gibbs P, Sieber OM. Williams DS, et al. Among authors: sakthianandeswaren a. Mod Pathol. 2020 Jul;33(7):1420-1432. doi: 10.1038/s41379-020-0496-1. Epub 2020 Feb 11. Mod Pathol. 2020. PMID: 32047231 Free article.
Immunoscore-has it scored for colon cancer precision medicine?
Jorissen RN, Sakthianandeswaren A, Sieber OM. Jorissen RN, et al. Among authors: sakthianandeswaren a. Ann Transl Med. 2018 Nov;6(Suppl 1):S23. doi: 10.21037/atm.2018.09.29. Ann Transl Med. 2018. PMID: 30613598 Free PMC article. No abstract available.
MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.
Sakthianandeswaren A, Parsons MJ, Mouradov D, MacKinnon RN, Catimel B, Liu S, Palmieri M, Love C, Jorissen RN, Li S, Whitehead L, Putoczki TL, Preaudet A, Tsui C, Nowell CJ, Ward RL, Hawkins NJ, Desai J, Gibbs P, Ernst M, Street I, Buchert M, Sieber OM. Sakthianandeswaren A, et al. Cancer Discov. 2018 Aug;8(8):988-1005. doi: 10.1158/2159-8290.CD-17-0909. Epub 2018 Jun 7. Cancer Discov. 2018. PMID: 29880585
25 results