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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M. Komatsu M, et al. Among authors: sakamoto a. Nat Cell Biol. 2010 Mar;12(3):213-23. doi: 10.1038/ncb2021. Epub 2010 Feb 21. Nat Cell Biol. 2010. PMID: 20173742
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komatsu M. Inami Y, et al. Among authors: sakamoto a. J Cell Biol. 2011 Apr 18;193(2):275-84. doi: 10.1083/jcb.201102031. Epub 2011 Apr 11. J Cell Biol. 2011. PMID: 21482715 Free PMC article.
Autophagy-deficient mice develop multiple liver tumors.
Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, Eishi Y, Hino O, Tanaka K, Mizushima N. Takamura A, et al. Among authors: sakamoto a. Genes Dev. 2011 Apr 15;25(8):795-800. doi: 10.1101/gad.2016211. Genes Dev. 2011. PMID: 21498569 Free PMC article.
eIF2B-capturing viral protein NSs suppresses the integrated stress response.
Kashiwagi K, Shichino Y, Osaki T, Sakamoto A, Nishimoto M, Takahashi M, Mito M, Weber F, Ikeuchi Y, Iwasaki S, Ito T. Kashiwagi K, et al. Among authors: sakamoto a. Nat Commun. 2021 Dec 7;12(1):7102. doi: 10.1038/s41467-021-27337-x. Nat Commun. 2021. PMID: 34876589 Free PMC article.
The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA.
Iwasaki S, Iwasaki W, Takahashi M, Sakamoto A, Watanabe C, Shichino Y, Floor SN, Fujiwara K, Mito M, Dodo K, Sodeoka M, Imataka H, Honma T, Fukuzawa K, Ito T, Ingolia NT. Iwasaki S, et al. Among authors: sakamoto a. Mol Cell. 2019 Feb 21;73(4):738-748.e9. doi: 10.1016/j.molcel.2018.11.026. Epub 2018 Dec 27. Mol Cell. 2019. PMID: 30595437 Free PMC article.
Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism.
Murayama K, Shirouzu M, Kawasaki Y, Kato-Murayama M, Hanawa-Suetsugu K, Sakamoto A, Katsura Y, Suenaga A, Toyama M, Terada T, Taiji M, Akiyama T, Yokoyama S. Murayama K, et al. Among authors: sakamoto a. J Biol Chem. 2007 Feb 16;282(7):4238-4242. doi: 10.1074/jbc.C600234200. Epub 2006 Dec 26. J Biol Chem. 2007. PMID: 17190834 Free article.
1,860 results