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Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State.
Kurnik M, Sahin C, Andersen CB, Lorenzen N, Giehm L, Mohammad-Beigi H, Jessen CM, Pedersen JS, Christiansen G, Petersen SV, Staal R, Krishnamurthy G, Pitts K, Reinhart PH, Mulder FAA, Mente S, Hirst WD, Otzen DE. Kurnik M, et al. Among authors: sahin c. Cell Chem Biol. 2018 Nov 15;25(11):1389-1402.e9. doi: 10.1016/j.chembiol.2018.08.005. Epub 2018 Sep 6. Cell Chem Biol. 2018. PMID: 30197194 Free article.
Early events in copper-ion catalyzed oxidation of α-synuclein.
Tiwari MK, Leinisch F, Sahin C, Møller IM, Otzen DE, Davies MJ, Bjerrum MJ. Tiwari MK, et al. Among authors: sahin c. Free Radic Biol Med. 2018 Jun;121:38-50. doi: 10.1016/j.freeradbiomed.2018.04.559. Epub 2018 Apr 22. Free Radic Biol Med. 2018. PMID: 29689296
Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity.
Mohammad-Beigi H, Aliakbari F, Sahin C, Lomax C, Tawfike A, Schafer NP, Amiri-Nowdijeh A, Eskandari H, Møller IM, Hosseini-Mazinani M, Christiansen G, Ward JL, Morshedi D, Otzen DE. Mohammad-Beigi H, et al. Among authors: sahin c. J Biol Chem. 2019 Mar 15;294(11):4215-4232. doi: 10.1074/jbc.RA118.005723. Epub 2019 Jan 17. J Biol Chem. 2019. PMID: 30655291 Free PMC article.
Mechanistic Understanding of the Interactions between Nano-Objects with Different Surface Properties and α-Synuclein.
Mohammad-Beigi H, Hosseini A, Adeli M, Ejtehadi MR, Christiansen G, Sahin C, Tu Z, Tavakol M, Dilmaghani-Marand A, Nabipour I, Farzadfar F, Otzen DE, Mahmoudi M, Hajipour MJ. Mohammad-Beigi H, et al. Among authors: sahin c. ACS Nano. 2019 Mar 26;13(3):3243-3256. doi: 10.1021/acsnano.8b08983. Epub 2019 Feb 27. ACS Nano. 2019. PMID: 30810027
Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization.
Sahin C, Østerlund EC, Österlund N, Costeira-Paulo J, Pedersen JN, Christiansen G, Nielsen J, Grønnemose AL, Amstrup SK, Tiwari MK, Rao RSP, Bjerrum MJ, Ilag LL, Davies MJ, Marklund EG, Pedersen JS, Landreh M, Møller IM, Jørgensen TJD, Otzen DE. Sahin C, et al. J Am Chem Soc. 2022 Jul 13;144(27):11949-11954. doi: 10.1021/jacs.2c03607. Epub 2022 Jun 24. J Am Chem Soc. 2022. PMID: 35749730 Free PMC article.
360 results