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High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo.
Huayamares SG, Lokugamage MP, Rab R, Da Silva Sanchez AJ, Kim H, Radmand A, Loughrey D, Lian L, Hou Y, Achyut BR, Ehrhardt A, Hong JS, Sago CD, Paunovska K, Echeverri ES, Vanover D, Santangelo PJ, Sorscher EJ, Dahlman JE. Huayamares SG, et al. Among authors: sago cd. J Control Release. 2023 May;357:394-403. doi: 10.1016/j.jconrel.2023.04.005. Epub 2023 Apr 12. J Control Release. 2023. PMID: 37028451 Free PMC article.
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing.
Sago CD, Lokugamage MP, Paunovska K, Vanover DA, Monaco CM, Shah NN, Gamboa Castro M, Anderson SE, Rudoltz TG, Lando GN, Munnilal Tiwari P, Kirschman JL, Willett N, Jang YC, Santangelo PJ, Bryksin AV, Dahlman JE. Sago CD, et al. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9944-E9952. doi: 10.1073/pnas.1811276115. Epub 2018 Oct 1. Proc Natl Acad Sci U S A. 2018. PMID: 30275336 Free PMC article.
Testing thousands of nanoparticles in vivo using DNA barcodes.
Lokugamage MP, Sago CD, Dahlman JE. Lokugamage MP, et al. Among authors: sago cd. Curr Opin Biomed Eng. 2018 Sep;7:1-8. doi: 10.1016/j.cobme.2018.08.001. Epub 2018 Aug 21. Curr Opin Biomed Eng. 2018. PMID: 30931416 Free PMC article.
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver.
Sago CD, Lokugamage MP, Loughrey D, Lindsay KE, Hincapie R, Krupczak BR, Kalathoor S, Sato M, Echeverri ES, Fitzgerald JP, Gan Z, Gamboa L, Paunovska K, Sanhueza CA, Hatit MZC, Finn MG, Santangelo PJ, Dahlman JE. Sago CD, et al. Nat Biomed Eng. 2022 Feb;6(2):157-167. doi: 10.1038/s41551-022-00847-9. Epub 2022 Feb 21. Nat Biomed Eng. 2022. PMID: 35190679
A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation.
Paunovska K, Sago CD, Monaco CM, Hudson WH, Castro MG, Rudoltz TG, Kalathoor S, Vanover DA, Santangelo PJ, Ahmed R, Bryksin AV, Dahlman JE. Paunovska K, et al. Among authors: sago cd. Nano Lett. 2018 Mar 14;18(3):2148-2157. doi: 10.1021/acs.nanolett.8b00432. Epub 2018 Mar 5. Nano Lett. 2018. PMID: 29489381 Free PMC article.
14 results