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Daphnanes diterpenes from the latex of Hura crepitans L. and their PKCζ-dependent anti-proliferative activity on colorectal cancer cells.
Crossay E, Jullian V, Trinel M, Sagnat D, Hamel D, Groppi E, Rolland C, Stigliani JL, Mejia K, Cabanillas BJ, Alric L, Buscail E, El Kalamouni C, Mavingui P, Deraison C, Racaud-Sultan C, Fabre N. Crossay E, et al. Among authors: sagnat d. Bioorg Med Chem. 2023 Jul 15;90:117366. doi: 10.1016/j.bmc.2023.117366. Epub 2023 Jun 7. Bioorg Med Chem. 2023. PMID: 37329676 Free article.
Sexual dimorphism in PAR2-dependent regulation of primitive colonic cells.
Noguerol J, Roustan PJ, N'Taye M, Delcombel L, Rolland C, Guiraud L, Sagnat D, Edir A, Bonnart C, Denadai-Souza A, Deraison C, Vergnolle N, Racaud-Sultan C. Noguerol J, et al. Among authors: sagnat d. Biol Sex Differ. 2019 Sep 6;10(1):47. doi: 10.1186/s13293-019-0262-6. Biol Sex Differ. 2019. PMID: 31492202 Free PMC article.
Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation.
Motta JP, Rolland C, Edir A, Florence AC, Sagnat D, Bonnart C, Rousset P, Guiraud L, Quaranta-Nicaise M, Mas E, Bonnet D, Verdu EF, McKay DM, Buscail E, Alric L, Vergnolle N, Deraison C. Motta JP, et al. Among authors: sagnat d. Mucosal Immunol. 2021 May;14(3):667-678. doi: 10.1038/s41385-021-00375-w. Epub 2021 Mar 5. Mucosal Immunol. 2021. PMID: 33674762 Free PMC article.
Prenatal stress induces changes in PAR2- and M3-dependent regulation of colon primitive cells.
Berger M, Guiraud L, Dumas A, Sagnat D, Payros G, Rolland C, Vergnolle N, Deraison C, Cenac N, Racaud-Sultan C. Berger M, et al. Among authors: sagnat d. Am J Physiol Gastrointest Liver Physiol. 2022 Dec 1;323(6):G609-G626. doi: 10.1152/ajpgi.00061.2022. Epub 2022 Oct 25. Am J Physiol Gastrointest Liver Physiol. 2022. PMID: 36283083 Free PMC article.
Increased Mucosal Thrombin is Associated with Crohn's Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation.
Motta JP, Palese S, Giorgio C, Chapman K, Denadai-Souza A, Rousset P, Sagnat D, Guiraud L, Edir A, Seguy C, Alric L, Bonnet D, Bournet B, Buscail L, Gilletta C, Buret AG, Wallace JL, Hollenberg MD, Oswald E, Barocelli E, Le Grand S, Le Grand B, Deraison C, Vergnolle N. Motta JP, et al. Among authors: sagnat d. J Crohns Colitis. 2021 May 4;15(5):787-799. doi: 10.1093/ecco-jcc/jjaa229. J Crohns Colitis. 2021. PMID: 33201214 Free PMC article.
Active thrombin produced by the intestinal epithelium controls mucosal biofilms.
Motta JP, Denadai-Souza A, Sagnat D, Guiraud L, Edir A, Bonnart C, Sebbag M, Rousset P, Lapeyre A, Seguy C, Mathurine-Thomas N, Galipeau HJ, Bonnet D, Alric L, Buret AG, Wallace JL, Dufour A, Verdu EF, Hollenberg MD, Oswald E, Serino M, Deraison C, Vergnolle N. Motta JP, et al. Among authors: sagnat d. Nat Commun. 2019 Jul 19;10(1):3224. doi: 10.1038/s41467-019-11140-w. Nat Commun. 2019. PMID: 31324782 Free PMC article.
Chymotrypsin activity signals to intestinal epithelium by protease-activated receptor-dependent mechanisms.
Guignard S, Saifeddine M, Mihara K, Motahhary M, Savignac M, Guiraud L, Sagnat D, Sebbag M, Khou S, Rolland C, Edir A, Bournet B, Buscail L, Buscail E, Alric L, Camare C, Ambli M, Vergnolle N, Hollenberg MD, Deraison C, Bonnart C. Guignard S, et al. Among authors: sagnat d. Br J Pharmacol. 2024 Apr 18. doi: 10.1111/bph.16341. Online ahead of print. Br J Pharmacol. 2024. PMID: 38637276