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Blockade of the protease ADAM17 ameliorates experimental pancreatitis.
Saad MI, Weng T, Lundy J, Gearing LJ, West AC, Harpur CM, Alanazi M, Hodges C, Croagh D, Kumar B, Sagi I, Rose-John S, Jenkins BJ. Saad MI, et al. Among authors: sagi i. Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2213744119. doi: 10.1073/pnas.2213744119. Epub 2022 Oct 10. Proc Natl Acad Sci U S A. 2022. PMID: 36215509 Free PMC article.
ADAM17 substrate release in proximal tubule drives kidney fibrosis.
Kefaloyianni E, Muthu ML, Kaeppler J, Sun X, Sabbisetti V, Chalaris A, Rose-John S, Wong E, Sagi I, Waikar SS, Rennke H, Humphreys BD, Bonventre JV, Herrlich A. Kefaloyianni E, et al. Among authors: sagi i. JCI Insight. 2016 Aug 18;1(13):e87023. doi: 10.1172/jci.insight.87023. JCI Insight. 2016. PMID: 27642633 Free PMC article.
ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.
Saad MI, Alhayyani S, McLeod L, Yu L, Alanazi M, Deswaerte V, Tang K, Jarde T, Smith JA, Prodanovic Z, Tate MD, Balic JJ, Watkins DN, Cain JE, Bozinovski S, Algar E, Kohmoto T, Ebi H, Ferlin W, Garbers C, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ. Saad MI, et al. Among authors: sagi i. EMBO Mol Med. 2019 Apr;11(4):e9976. doi: 10.15252/emmm.201809976. EMBO Mol Med. 2019. PMID: 30833304 Free PMC article.
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.
Wichert R, Scharfenberg F, Colmorgen C, Koudelka T, Schwarz J, Wetzel S, Potempa B, Potempa J, Bartsch JW, Sagi I, Tholey A, Saftig P, Rose-John S, Becker-Pauly C. Wichert R, et al. Among authors: sagi i. FASEB J. 2019 Nov;33(11):11925-11940. doi: 10.1096/fj.201801371R. Epub 2019 Aug 9. FASEB J. 2019. PMID: 31381863 Free PMC article.
., Schwarz, J., Wetzel, S., Potempa, B., Potempa, J., Bartsch, J. W., Sagi, I., Tholey, A., Saftig, P., Rose-John, S., Becker-Pauly, C. ...
., Schwarz, J., Wetzel, S., Potempa, B., Potempa, J., Bartsch, J. W., Sagi, I., Tholey, A., Saftig, P., Rose-John, S., Becker- …
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.
Bolik J, Krause F, Stevanovic M, Gandraß M, Thomsen I, Schacht SS, Rieser E, Müller M, Schumacher N, Fritsch J, Wichert R, Galun E, Bergmann J, Röder C, Schafmayer C, Egberts JH, Becker-Pauly C, Saftig P, Lucius R, Schneider-Brachert W, Barikbin R, Adam D, Voss M, Hitzl W, Krüger A, Strilic B, Sagi I, Walczak H, Rose-John S, Schmidt-Arras D. Bolik J, et al. Among authors: sagi i. J Exp Med. 2022 Jan 3;219(1):e20201039. doi: 10.1084/jem.20201039. Epub 2021 Dec 17. J Exp Med. 2022. PMID: 34919140 Free PMC article.
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