Sagan SM - Search Results

1

Elucidating the distinct contributions of miR-122 in the HCV life cycle reveals insights into virion assembly.

Rheault M, Cousineau SE, Fox DR, Abram QH, Sagan SM. Rheault M, et al. Among authors: sagan sm. Nucleic Acids Res. 2023 Mar 21;51(5):2447-2463. doi: 10.1093/nar/gkad094. Nucleic Acids Res. 2023. PMID: 36807979 Free PMC article.

2

miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5' end from the cellular pyrophosphatases, DOM3Z and DUSP11.

Amador-Cañizares Y, Bernier A, Wilson JA, Sagan SM. Amador-Cañizares Y, et al. Among authors: sagan sm. Nucleic Acids Res. 2018 Jun 1;46(10):5139-5158. doi: 10.1093/nar/gky273. Nucleic Acids Res. 2018. PMID: 29672716 Free PMC article.

3

Beyond sites 1 and 2, miR-122 target sites in the HCV genome have negligible contributions to HCV RNA accumulation in cell culture.

Bernier A, Sagan SM. Bernier A, et al. Among authors: sagan sm. J Gen Virol. 2019 Feb;100(2):217-226. doi: 10.1099/jgv.0.001217. Epub 2019 Jan 17. J Gen Virol. 2019. PMID: 30652963

4

miR-122 and Ago interactions with the HCV genome alter the structure of the viral 5' terminus.

Chahal J, Gebert LFR, Gan HH, Camacho E, Gunsalus KC, MacRae IJ, Sagan SM. Chahal J, et al. Among authors: sagan sm. Nucleic Acids Res. 2019 Jun 4;47(10):5307-5324. doi: 10.1093/nar/gkz194. Nucleic Acids Res. 2019. PMID: 30941417 Free PMC article.

5

Molecular Determinants of Flavivirus Virion Assembly.

Barnard TR, Abram QH, Lin QF, Wang AB, Sagan SM. Barnard TR, et al. Among authors: sagan sm. Trends Biochem Sci. 2021 May;46(5):378-390. doi: 10.1016/j.tibs.2020.12.007. Epub 2021 Jan 7. Trends Biochem Sci. 2021. PMID: 33423940 Free article. Review.

6

Poly(rC)-Binding Protein 1 Limits Hepatitis C Virus Virion Assembly and Secretion.

Cousineau SE, Rheault M, Sagan SM. Cousineau SE, et al. Among authors: sagan sm. Viruses. 2022 Jan 29;14(2):291. doi: 10.3390/v14020291. Viruses. 2022. PMID: 35215884 Free PMC article.

7

The 7th Canadian Symposium on Hepatitis C Virus: "Toward Elimination of HCV: How to Get There".

Cheng ML, Abdel-Hakeem MS, Cousineau SE, Grebely J, Marshall AD, Saeed S, Sagan SM, Shoukry NH, Feld JJ, MacParland SA. Cheng ML, et al. Among authors: sagan sm. Can Liver J. 2018 Oct 3;1(3):139-152. doi: 10.3138/canlivj.2018-0018. eCollection 2018 Summer. Can Liver J. 2018. PMID: 35991324 Free PMC article.

8

The 8^th Canadian Symposium on Hepatitis C virus: "Improving diagnosis and linkage to care".

Cousineau SE, Erman A, Liu L, Saeed S, Fradette L, Feld JJ, Grebely J, MacParland SA, Shoukry NH, Sebastiani G, Sagan SM; Canadian Network on Hepatitis C (CanHepC). Cousineau SE, et al. Among authors: sagan sm. Can Liver J. 2020 Feb 24;3(1):3-14. doi: 10.3138/canlivj.2019-0032. eCollection 2020 Winter. Can Liver J. 2020. PMID: 35992037 Free PMC article.

9

Hepatitis C virus and human miR-122: insights from the bench to the clinic.

Wilson JA, Sagan SM. Wilson JA, et al. Among authors: sagan sm. Curr Opin Virol. 2014 Aug;7:11-8. doi: 10.1016/j.coviro.2014.03.005. Epub 2014 Apr 11. Curr Opin Virol. 2014. PMID: 24721497 Review.

10

miR-122-based therapies select for three distinct resistance mechanisms based on alterations in RNA structure.

Chahal J, Gebert LFR, Camargo C, MacRae IJ, Sagan SM. Chahal J, et al. Among authors: sagan sm. Proc Natl Acad Sci U S A. 2021 Aug 17;118(33):e2103671118. doi: 10.1073/pnas.2103671118. Proc Natl Acad Sci U S A. 2021. PMID: 34385308 Free PMC article.

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