Sagae Y - Search Results

1

Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis.

Tabata J, Nakaoku T, Araki M, Yoshino R, Kohsaka S, Otsuka A, Ikegami M, Ui A, Kanno SI, Miyoshi K, Matsumoto S, Sagae Y, Yasui A, Sekijima M, Mano H, Okuno Y, Okamoto A, Kohno T. Tabata J, et al. Among authors: sagae y. Cancer Res. 2022 Oct 17;82(20):3751-3762. doi: 10.1158/0008-5472.CAN-22-0834. Cancer Res. 2022. PMID: 36166639 Free PMC article.

2

Improving the Accuracy of Protein-Ligand Binding Mode Prediction Using a Molecular Dynamics-Based Pocket Generation Approach.

Araki M, Iwata H, Ma B, Fujita A, Terayama K, Sagae Y, Ono F, Tsuda K, Kamiya N, Okuno Y. Araki M, et al. Among authors: sagae y. J Comput Chem. 2018 Dec 15;39(32):2679-2689. doi: 10.1002/jcc.25715. J Comput Chem. 2018. PMID: 30515903

3

Identification of a new class of non-electrophilic TRPA1 agonists by a structure-based virtual screening approach.

Araki M, Kanda N, Iwata H, Sagae Y, Masuda K, Okuno Y. Araki M, et al. Among authors: sagae y. Bioorg Med Chem Lett. 2020 Jun 1;30(11):127142. doi: 10.1016/j.bmcl.2020.127142. Epub 2020 Mar 26. Bioorg Med Chem Lett. 2020. PMID: 32249116

4

Hydrophobic interactions at subsite S1' of human dipeptidyl peptidase IV contribute significantly to the inhibitory effect of tripeptides.

Araki M, Kanegawa N, Iwata H, Sagae Y, Ito K, Masuda K, Okuno Y. Araki M, et al. Among authors: sagae y. Heliyon. 2020 Jun 23;6(6):e04227. doi: 10.1016/j.heliyon.2020.e04227. eCollection 2020 Jun. Heliyon. 2020. PMID: 32613113 Free PMC article.

5

Discovery of natural TRPA1 activators through pharmacophore-based virtual screening and a biological assay.

Iwata H, Kanda N, Araki M, Sagae Y, Masuda K, Okuno Y. Iwata H, et al. Among authors: sagae y. Bioorg Med Chem Lett. 2021 Jan 1;31:127639. doi: 10.1016/j.bmcl.2020.127639. Epub 2020 Oct 29. Bioorg Med Chem Lett. 2021. PMID: 33129991

6

Novel Resistance Mechanisms Including L1196Q, P1094H, and R1248_D1249 Insertion in Three Patients With NSCLC After ALK Tyrosine Kinase Inhibitor Treatment.

Furuta H, Araki M, Masago K, Sagae Y, Fujita S, Seto K, Shimizu J, Horio Y, Sasaki E, Hosoda W, Katayama R, Okuno Y, Hida T. Furuta H, et al. Among authors: sagae y. J Thorac Oncol. 2021 Mar;16(3):477-482. doi: 10.1016/j.jtho.2020.09.023. Epub 2020 Nov 6. J Thorac Oncol. 2021. PMID: 33166721 Free article.

7

Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer.

Mizuta H, Okada K, Araki M, Adachi J, Takemoto A, Kutkowska J, Maruyama K, Yanagitani N, Oh-Hara T, Watanabe K, Tamai K, Friboulet L, Katayama K, Ma B, Sasakura Y, Sagae Y, Kukimoto-Niino M, Shirouzu M, Takagi S, Simizu S, Nishio M, Okuno Y, Fujita N, Katayama R. Mizuta H, et al. Among authors: sagae y. Nat Commun. 2021 Feb 24;12(1):1261. doi: 10.1038/s41467-021-21396-w. Nat Commun. 2021. PMID: 33627640 Free PMC article.

8

Exploring ligand binding pathways on proteins using hypersound-accelerated molecular dynamics.

Araki M, Matsumoto S, Bekker GJ, Isaka Y, Sagae Y, Kamiya N, Okuno Y. Araki M, et al. Among authors: sagae y. Nat Commun. 2021 May 14;12(1):2793. doi: 10.1038/s41467-021-23157-1. Nat Commun. 2021. PMID: 33990583 Free PMC article.

9

Integrated approach to functional analysis of an ERBB2 variant of unknown significance detected by a cancer gene panel test.

Harada Y, Sato A, Araki M, Matsumoto S, Isaka Y, Sagae Y, Abe T, Aoyagi Y, Sueoka E, Okuno Y, Kimura S, Sueoka-Aragane N. Harada Y, et al. Among authors: sagae y. Cell Oncol (Dordr). 2022 Feb;45(1):121-134. doi: 10.1007/s13402-021-00656-3. Epub 2022 Jan 8. Cell Oncol (Dordr). 2022. PMID: 34997908 Free PMC article.

10

Sensitivity to dabrafenib and trametinib treatments in patients with non-small-cell cancer harboring BRAF compound mutations: A pooled analysis of BRAF p.V600E-positive advanced non-small-cell lung cancer.

Seto K, Shimizu J, Masago K, Araki M, Katayama R, Sagae Y, Fujita S, Horio Y, Sasaki E, Kuroda H, Okubo K, Okuno Y, Hida T. Seto K, et al. Among authors: sagae y. Cancer Genet. 2022 Aug;266-267:1-6. doi: 10.1016/j.cancergen.2022.05.001. Epub 2022 May 11. Cancer Genet. 2022. PMID: 35598548

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