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Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC.
Hawthorne RN, Blazeski A, Lowenthal J, Kannan S, Teuben R, DiSilvestre D, Morrissette-McAlmon J, Saffitz JE, Boheler KR, James CA, Chelko SP, Tomaselli G, Tung L. Hawthorne RN, et al. Among authors: saffitz je. J Clin Med. 2021 Jul 10;10(14):3061. doi: 10.3390/jcm10143061. J Clin Med. 2021. PMID: 34300226 Free PMC article.
Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells.
Asimaki A, Protonotarios A, James CA, Chelko SP, Tichnell C, Murray B, Tsatsopoulou A, Anastasakis A, te Riele A, Kléber AG, Judge DP, Calkins H, Saffitz JE. Asimaki A, et al. Among authors: saffitz je. Circ Arrhythm Electrophysiol. 2016 Feb;9(2):e003688. doi: 10.1161/CIRCEP.115.003688. Circ Arrhythm Electrophysiol. 2016. PMID: 26850880 Free PMC article.
Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy.
Chelko SP, Asimaki A, Andersen P, Bedja D, Amat-Alarcon N, DeMazumder D, Jasti R, MacRae CA, Leber R, Kleber AG, Saffitz JE, Judge DP. Chelko SP, et al. Among authors: saffitz je. JCI Insight. 2016 Apr 21;1(5):e85923. doi: 10.1172/jci.insight.85923. JCI Insight. 2016. PMID: 27170944 Free PMC article.
Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy.
Chelko SP, Asimaki A, Lowenthal J, Bueno-Beti C, Bedja D, Scalco A, Amat-Alarcon N, Andersen P, Judge DP, Tung L, Saffitz JE. Chelko SP, et al. Among authors: saffitz je. Circulation. 2019 Oct 29;140(18):1491-1505. doi: 10.1161/CIRCULATIONAHA.119.040676. Epub 2019 Sep 19. Circulation. 2019. PMID: 31533459 Free PMC article.
Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy.
Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-Codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O'Rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N. Chelko SP, et al. Among authors: saffitz je. Sci Transl Med. 2021 Feb 17;13(581):eabf0891. doi: 10.1126/scitranslmed.abf0891. Sci Transl Med. 2021. PMID: 33597260 Free PMC article.
A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy.
Asimaki A, Tandri H, Huang H, Halushka MK, Gautam S, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, McKenna WJ, Calkins H, Saffitz JE. Asimaki A, et al. Among authors: saffitz je. N Engl J Med. 2009 Mar 12;360(11):1075-84. doi: 10.1056/NEJMoa0808138. N Engl J Med. 2009. PMID: 19279339 Free article.
2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy.
Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W. Towbin JA, et al. Among authors: saffitz je. Heart Rhythm. 2019 Nov;16(11):e301-e372. doi: 10.1016/j.hrthm.2019.05.007. Epub 2019 May 9. Heart Rhythm. 2019. PMID: 31078652
313 results