Sadowski T - Search Results

1

Proteomic Profiling of Cardiomyocyte-Specific Cathepsin A Overexpression Links Cathepsin A to the Oxidative Stress Response.

Petrera A, Kern U, Linz D, Gomez-Auli A, Hohl M, Gassenhuber J, Sadowski T, Schilling O. Petrera A, et al. Among authors: sadowski t. J Proteome Res. 2016 Sep 2;15(9):3188-95. doi: 10.1021/acs.jproteome.6b00413. Epub 2016 Jul 28. J Proteome Res. 2016. PMID: 27432266

2

Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels.

Petrera A, Gassenhuber J, Ruf S, Gunasekaran D, Esser J, Shahinian JH, Hübschle T, Rütten H, Sadowski T, Schilling O. Petrera A, et al. Among authors: sadowski t. J Transl Med. 2016 May 31;14(1):153. doi: 10.1186/s12967-016-0907-8. J Transl Med. 2016. PMID: 27246731 Free PMC article.

3

Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats.

Linz D, Hohl M, Dhein S, Ruf S, Reil JC, Kabiri M, Wohlfart P, Verheule S, Böhm M, Sadowski T, Schotten U. Linz D, et al. Among authors: sadowski t. Cardiovasc Res. 2016 Jun 1;110(3):371-80. doi: 10.1093/cvr/cvw071. Epub 2016 Mar 31. Cardiovasc Res. 2016. PMID: 27032673

4

Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice.

Hohl M, Mayr M, Lang L, Nickel AG, Barallobre-Barreiro J, Yin X, Speer T, Selejan SR, Goettsch C, Erb K, Fecher-Trost C, Reil JC, Linz B, Ruf S, Hübschle T, Maack C, Böhm M, Sadowski T, Linz D. Hohl M, et al. Among authors: sadowski t. J Biol Chem. 2020 Sep 4;295(36):12605-12617. doi: 10.1074/jbc.RA120.013488. Epub 2020 Jul 9. J Biol Chem. 2020. PMID: 32647007 Free PMC article.

5

Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion.

Hohl M, Erb K, Lang L, Ruf S, Hübschle T, Dhein S, Linz W, Elliott AD, Sanders P, Zamyatkin O, Böhm M, Schotten U, Sadowski T, Linz D. Hohl M, et al. Among authors: sadowski t. JACC Basic Transl Sci. 2019 Jun 24;4(3):332-344. doi: 10.1016/j.jacbts.2019.01.008. eCollection 2019 Jun. JACC Basic Transl Sci. 2019. PMID: 31312757 Free PMC article.

6

Novel β-amino acid derivatives as inhibitors of cathepsin A.

Ruf S, Buning C, Schreuder H, Horstick G, Linz W, Olpp T, Pernerstorfer J, Hiss K, Kroll K, Kannt A, Kohlmann M, Linz D, Hübschle T, Rütten H, Wirth K, Schmidt T, Sadowski T. Ruf S, et al. Among authors: sadowski t. J Med Chem. 2012 Sep 13;55(17):7636-49. doi: 10.1021/jm300663n. Epub 2012 Aug 16. J Med Chem. 2012. PMID: 22861813

7

Inhibition of CatA: an emerging strategy for the treatment of heart failure.

Ruf S, Buning C, Schreuder H, Linz W, Hübschle T, Linz D, Ruetten H, Wirth K, Sadowski T. Ruf S, et al. Among authors: sadowski t. Future Med Chem. 2013 Mar;5(4):399-409. doi: 10.4155/fmc.13.24. Future Med Chem. 2013. PMID: 23495688

8

Tolerability, safety, and pharmacokinetics of the novel cathepsin A inhibitor SAR164653 in healthy subjects.

Tillner J, Lehmann A, Paehler T, Lukacs Z, Ruf S, Sadowski T, Pinquier JL, Ruetten H. Tillner J, et al. Among authors: sadowski t. Clin Pharmacol Drug Dev. 2016 Jan;5(1):57-68. doi: 10.1002/cpdd.201. Epub 2015 Sep 24. Clin Pharmacol Drug Dev. 2016. PMID: 27119579 Clinical Trial.

9

Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases.

Schreuder HA, Liesum A, Kroll K, Böhnisch B, Buning C, Ruf S, Sadowski T. Schreuder HA, et al. Among authors: sadowski t. Biochem Biophys Res Commun. 2014 Mar 7;445(2):451-6. doi: 10.1016/j.bbrc.2014.02.014. Epub 2014 Feb 12. Biochem Biophys Res Commun. 2014. PMID: 24530914

10

Long-term severe diabetes only leads to mild cardiac diastolic dysfunction in Zucker diabetic fatty rats.

Daniels A, Linz D, van Bilsen M, Rütten H, Sadowski T, Ruf S, Juretschke HP, Neumann-Haefelin C, Munts C, van der Vusse GJ, van Nieuwenhoven FA. Daniels A, et al. Among authors: sadowski t. Eur J Heart Fail. 2012 Feb;14(2):193-201. doi: 10.1093/eurjhf/hfr166. Eur J Heart Fail. 2012. PMID: 22253456 Free article.

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