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Inhibition of UBA6 by inosine augments tumour immunogenicity and responses.
Zhang L, Jiang L, Yu L, Li Q, Tian X, He J, Zeng L, Yang Y, Wang C, Wei Y, Jiang X, Li J, Ge X, Gu Q, Li J, Wu D, Sadler AJ, Yu D, Xu D, Gao Y, Yuan X, He B. Zhang L, et al. Among authors: sadler aj. Nat Commun. 2022 Sep 15;13(1):5413. doi: 10.1038/s41467-022-33116-z. Nat Commun. 2022. PMID: 36109526 Free PMC article.
BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs.
Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liaskos M, Gantier MP, Ying H, Yim HC, Hartland EL, Notini AJ, de Boer S, White SJ, Mansell A, Liu JP, Watkins DN, Gerondakis S, Williams BR, Xu D. Sadler AJ, et al. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1535-40. doi: 10.1073/pnas.1409728112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605927 Free PMC article.
The kinase activity of PKR represses inflammasome activity.
Yim HC, Wang D, Yu L, White CL, Faber PW, Williams BR, Sadler AJ. Yim HC, et al. Among authors: sadler aj. Cell Res. 2016 Mar;26(3):367-79. doi: 10.1038/cr.2016.11. Epub 2016 Jan 22. Cell Res. 2016. PMID: 26794869 Free PMC article.
Inflammasome activity is controlled by ZBTB16-dependent SUMOylation of ASC.
Dong D, Du Y, Fei X, Yang H, Li X, Yang X, Ma J, Huang S, Ma Z, Zheng J, Chan DW, Shi L, Li Y, Irving AT, Yuan X, Liu X, Ni P, Hu Y, Meng G, Peng Y, Sadler A, Xu D. Dong D, et al. Nat Commun. 2023 Dec 20;14(1):8465. doi: 10.1038/s41467-023-43945-1. Nat Commun. 2023. PMID: 38123560 Free PMC article.
Interferon-inducible antiviral effectors.
Sadler AJ, Williams BR. Sadler AJ, et al. Nat Rev Immunol. 2008 Jul;8(7):559-68. doi: 10.1038/nri2314. Nat Rev Immunol. 2008. PMID: 18575461 Free PMC article. Review.
46 results