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BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis.
Imianowski CJ, Whiteside SK, Lozano T, Evans AC, Benson JD, Courreges CJF, Sadiyah F, Lau CM, Zandhuis ND, Grant FM, Schuijs MJ, Vardaka P, Kuo P, Soilleux EJ, Yang J, Sun JC, Kurosaki T, Okkenhaug K, Halim TYF, Roychoudhuri R. Imianowski CJ, et al. Among authors: sadiyah f. J Exp Med. 2022 Dec 5;219(12):e20211476. doi: 10.1084/jem.20211476. Epub 2022 Sep 30. J Exp Med. 2022. PMID: 36178457 Free PMC article.
BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression.
Grant FM, Yang J, Nasrallah R, Clarke J, Sadiyah F, Whiteside SK, Imianowski CJ, Kuo P, Vardaka P, Todorov T, Zandhuis N, Patrascan I, Tough DF, Kometani K, Eil R, Kurosaki T, Okkenhaug K, Roychoudhuri R. Grant FM, et al. Among authors: sadiyah f. J Exp Med. 2020 Sep 7;217(9):e20190711. doi: 10.1084/jem.20190711. J Exp Med. 2020. PMID: 32515782 Free PMC article.
CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function.
Whiteside SK, Grant FM, Gyori DS, Conti AG, Imianowski CJ, Kuo P, Nasrallah R, Sadiyah F, Lira SA, Tacke F, Eil RL, Burton OT, Dooley J, Liston A, Okkenhaug K, Yang J, Roychoudhuri R. Whiteside SK, et al. Among authors: sadiyah f. Immunology. 2021 Aug;163(4):512-520. doi: 10.1111/imm.13337. Epub 2021 May 9. Immunology. 2021. PMID: 33838058 Free PMC article.
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells.
Nasrallah R, Imianowski CJ, Bossini-Castillo L, Grant FM, Dogan M, Placek L, Kozhaya L, Kuo P, Sadiyah F, Whiteside SK, Mumbach MR, Glinos D, Vardaka P, Whyte CE, Lozano T, Fujita T, Fujii H, Liston A, Andrews S, Cozzani A, Yang J, Mitra S, Lugli E, Chang HY, Unutmaz D, Trynka G, Roychoudhuri R. Nasrallah R, et al. Among authors: sadiyah f. Nature. 2020 Jul;583(7816):447-452. doi: 10.1038/s41586-020-2296-7. Epub 2020 May 13. Nature. 2020. PMID: 32499651 Free PMC article.
The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells.
Koh GCC, Boushaki S, Zhao SJ, Pregnall AM, Sadiyah F, Badja C, Memari Y, Georgakopoulos-Soares I, Nik-Zainal S. Koh GCC, et al. Among authors: sadiyah f. Nat Genet. 2024 Jan;56(1):23-26. doi: 10.1038/s41588-023-01602-9. Epub 2023 Nov 30. Nat Genet. 2024. PMID: 38036782 Free PMC article.