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Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin.
Toepfer CN, Wakimoto H, Garfinkel AC, McDonough B, Liao D, Jiang J, Tai AC, Gorham JM, Lunde IG, Lun M, Lynch TL 4th, McNamara JW, Sadayappan S, Redwood CS, Watkins HC, Seidman JG, Seidman CE. Toepfer CN, et al. Among authors: sadayappan s. Sci Transl Med. 2019 Jan 23;11(476):eaat1199. doi: 10.1126/scitranslmed.aat1199. Sci Transl Med. 2019. PMID: 30674652 Free PMC article.
Cardiac myosin-binding protein-C phosphorylation and cardiac function.
Sadayappan S, Gulick J, Osinska H, Martin LA, Hahn HS, Dorn GW 2nd, Klevitsky R, Seidman CE, Seidman JG, Robbins J. Sadayappan S, et al. Circ Res. 2005 Nov 25;97(11):1156-63. doi: 10.1161/01.RES.0000190605.79013.4d. Epub 2005 Oct 13. Circ Res. 2005. PMID: 16224063 Free PMC article.
Cardiac myosin binding protein C phosphorylation is cardioprotective.
Sadayappan S, Osinska H, Klevitsky R, Lorenz JN, Sargent M, Molkentin JD, Seidman CE, Seidman JG, Robbins J. Sadayappan S, et al. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16918-23. doi: 10.1073/pnas.0607069103. Epub 2006 Oct 30. Proc Natl Acad Sci U S A. 2006. PMID: 17075052 Free PMC article.
GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication.
Kuster DW, Sequeira V, Najafi A, Boontje NM, Wijnker PJ, Witjas-Paalberends ER, Marston SB, Dos Remedios CG, Carrier L, Demmers JA, Redwood C, Sadayappan S, van der Velden J. Kuster DW, et al. Among authors: sadayappan s. Circ Res. 2013 Feb 15;112(4):633-9. doi: 10.1161/CIRCRESAHA.112.275602. Epub 2012 Dec 31. Circ Res. 2013. PMID: 23277198 Free PMC article.
165 results