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Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice.
Chang CP, Wu CH, Song JS, Chou MC, Wong YC, Lin Y, Yeh TK, Sadani AA, Ou MH, Chen KH, Chen PH, Kuo PC, Tseng CT, Chang KH, Tseng SL, Chao YS, Hung MS, Shia KS. Chang CP, et al. Among authors: sadani aa. J Med Chem. 2013 Dec 27;56(24):9920-33. doi: 10.1021/jm401158e. Epub 2013 Dec 4. J Med Chem. 2013. PMID: 24224693
Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors.
Wu CH, Wang CJ, Chang CP, Cheng YC, Song JS, Jan JJ, Chou MC, Ke YY, Ma J, Wong YC, Hsieh TC, Tien YC, Gullen EA, Lo CF, Cheng CY, Liu YW, Sadani AA, Tsai CH, Hsieh HP, Tsou LK, Shia KS. Wu CH, et al. Among authors: sadani aa. J Med Chem. 2015 Feb 12;58(3):1452-65. doi: 10.1021/jm501772w. Epub 2015 Jan 28. J Med Chem. 2015. PMID: 25584630 Free PMC article.
Bromomethylthioindole Inspired Carbazole Hybrids as Promising Class of Anti-MRSA Agents.
Cheng CY, Chang CP, Lauderdale TY, Yu GY, Lee JC, Jhang YW, Wu CH, Ke YY, Sadani AA, Yeh CF, Huang IW, Kuo YP, Tsai DJ, Yeh TK, Tseng CT, Song JS, Liu YW, Tsou LK, Shia KS. Cheng CY, et al. Among authors: sadani aa. ACS Med Chem Lett. 2016 Oct 21;7(12):1191-1196. doi: 10.1021/acsmedchemlett.6b00289. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994762 Free PMC article.
Ureas: Applications in Drug Design.
Jagtap AD, Kondekar NB, Sadani AA, Chern JW. Jagtap AD, et al. Among authors: sadani aa. Curr Med Chem. 2017;24(6):622-651. doi: 10.2174/0929867323666161129124915. Curr Med Chem. 2017. PMID: 27897114 Review.