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Preclinical development of kinetin as a safe error-prone SARS-CoV-2 antiviral able to attenuate virus-induced inflammation.
Souza TML, Pinho VD, Setim CF, Sacramento CQ, Marcon R, Fintelman-Rodrigues N, Chaves OA, Heller M, Temerozo JR, Ferreira AC, Mattos M, Momo PB, Dias SSG, Gesto JSM, Pereira-Dutra F, Viola JPB, Queiroz-Junior CM, Guimarães LC, Chaves IM, Guimarães PPG, Costa VV, Teixeira MM, Bou-Habib DC, Bozza PT, Aguillón AR, Siqueira-Junior J, Macedo-Junior S, Andrade EL, Fadanni GP, Tolouei SEL, Potrich FB, Santos AA, Marques NF, Calixto JB, Rabi JA. Souza TML, et al. Among authors: sacramento cq. Nat Commun. 2023 Jan 13;14(1):199. doi: 10.1038/s41467-023-35928-z. Nat Commun. 2023. PMID: 36639383 Free PMC article.
Detection of the influenza A(H1N1)pdm09 virus carrying the K-15E, P83S and Q293H mutations in patients who have undergone bone marrow transplant.
Mesquita M, Resende P, Marttorelli A, Machado V, Sacramento CQ, Fintelman-Rodrigues N, Abrantes JL, Tavares R, Schirmer M, Siqueira MM, Souza TM. Mesquita M, et al. Among authors: sacramento cq. PLoS One. 2014 Apr 16;9(4):e94822. doi: 10.1371/journal.pone.0094822. eCollection 2014. PLoS One. 2014. PMID: 24740088 Free PMC article.
Aureonitol, a Fungi-Derived Tetrahydrofuran, Inhibits Influenza Replication by Targeting Its Surface Glycoprotein Hemagglutinin.
Sacramento CQ, Marttorelli A, Fintelman-Rodrigues N, de Freitas CS, de Melo GR, Rocha ME, Kaiser CR, Rodrigues KF, da Costa GL, Alves CM, Santos-Filho O, Barbosa JP, Souza TM. Sacramento CQ, et al. PLoS One. 2015 Oct 13;10(10):e0139236. doi: 10.1371/journal.pone.0139236. eCollection 2015. PLoS One. 2015. PMID: 26462111 Free PMC article.
1,2,3-Triazolyl-4-oxoquinolines: A feasible beginning for promising chemical structures to inhibit oseltamivir-resistant influenza A and B viruses.
Boechat Fda C, Sacramento CQ, Cunha AC, Sagrillo FS, Nogueira CM, Fintelman-Rodrigues N, Santos-Filho O, Riscado CS, Forezi Lda S, Faro LV, Brozeguini L, Marques IP, Ferreira VF, Souza TM, de Souza MC. Boechat Fda C, et al. Among authors: sacramento cq. Bioorg Med Chem. 2015 Dec 15;23(24):7777-84. doi: 10.1016/j.bmc.2015.11.028. Epub 2015 Nov 26. Bioorg Med Chem. 2015. PMID: 26643220 Free article.
The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication.
Sacramento CQ, de Melo GR, de Freitas CS, Rocha N, Hoelz LV, Miranda M, Fintelman-Rodrigues N, Marttorelli A, Ferreira AC, Barbosa-Lima G, Abrantes JL, Vieira YR, Bastos MM, de Mello Volotão E, Nunes EP, Tschoeke DA, Leomil L, Loiola EC, Trindade P, Rehen SK, Bozza FA, Bozza PT, Boechat N, Thompson FL, de Filippis AM, Brüning K, Souza TM. Sacramento CQ, et al. Sci Rep. 2017 Jan 18;7:40920. doi: 10.1038/srep40920. Sci Rep. 2017. PMID: 28098253 Free PMC article.
Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication.
Ferreira AC, Reis PA, de Freitas CS, Sacramento CQ, Villas Bôas Hoelz L, Bastos MM, Mattos M, Rocha N, Gomes de Azevedo Quintanilha I, da Silva Gouveia Pedrosa C, Rocha Quintino Souza L, Correia Loiola E, Trindade P, Rangel Vieira Y, Barbosa-Lima G, de Castro Faria Neto HC, Boechat N, Rehen SK, Brüning K, Bozza FA, Bozza PT, Souza TML. Ferreira AC, et al. Among authors: sacramento cq. Antimicrob Agents Chemother. 2019 Jan 29;63(2):e01389-18. doi: 10.1128/AAC.01389-18. Print 2019 Feb. Antimicrob Agents Chemother. 2019. PMID: 30455237 Free PMC article.
Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo.
de Freitas CS, Higa LM, Sacramento CQ, Ferreira AC, Reis PA, Delvecchio R, Monteiro FL, Barbosa-Lima G, James Westgarth H, Vieira YR, Mattos M, Rocha N, Hoelz LVB, Leme RPP, Bastos MM, Rodrigues GOL, Lopes CEM, Queiroz-Junior CM, Lima CX, Costa VV, Teixeira MM, Bozza FA, Bozza PT, Boechat N, Tanuri A, Souza TML. de Freitas CS, et al. Among authors: sacramento cq. PLoS Negl Trop Dis. 2019 Jan 30;13(1):e0007072. doi: 10.1371/journal.pntd.0007072. eCollection 2019 Jan. PLoS Negl Trop Dis. 2019. PMID: 30699122 Free PMC article.
48 results