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Human Fc gamma receptor IIIA blockade inhibits platelet destruction in a humanized murine model of ITP.
Gil Gonzalez L, Won KD, Tawhidi Z, Cummins E, Cruz-Leal Y, Tundidor Cabado Y, Sachs UJ, Norris PAA, Shan Y, Bhakta V, Li J, Samudio I, Silva-Moreno B, Cerna-Portillo L, Pavon Oro A, Bergqvist P, Chan P, Moorehead A, Sholzberg M, Sheffield WP, Lazarus AH. Gil Gonzalez L, et al. Among authors: sachs uj. Blood Adv. 2024 Apr 23;8(8):1869-1879. doi: 10.1182/bloodadvances.2023012155. Blood Adv. 2024. PMID: 38330193 Free PMC article.
Glycoprotein V is a relevant immune target in patients with immune thrombocytopenia.
Vollenberg R, Jouni R, Norris PAA, Burg-Roderfeld M, Cooper N, Rummel MJ, Bein G, Marini I, Bayat B, Burack R, Lazarus AH, Bakchoul T, Sachs UJ. Vollenberg R, et al. Among authors: sachs uj. Haematologica. 2019 Jun;104(6):1237-1243. doi: 10.3324/haematol.2018.211086. Epub 2019 Mar 28. Haematologica. 2019. PMID: 30923095 Free PMC article.
FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia.
Norris PAA, Segel GB, Burack WR, Sachs UJ, Lissenberg-Thunnissen SN, Vidarsson G, Bayat B, Cserti-Gazdewich CM, Callum J, Lin Y, Branch D, Kapur R, Semple JW, Lazarus AH. Norris PAA, et al. Among authors: sachs uj. Haematologica. 2021 Jan 1;106(1):250-254. doi: 10.3324/haematol.2020.248385. Haematologica. 2021. PMID: 32107327 Free PMC article. No abstract available.
144 results