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Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells.
Roudnicky F, Zhang JD, Kim BK, Pandya NJ, Lan Y, Sach-Peltason L, Ragelle H, Strassburger P, Gruener S, Lazendic M, Uhles S, Revelant F, Eidam O, Sturm G, Kueppers V, Christensen K, Goldstein LD, Tzouros M, Banfai B, Modrusan Z, Graf M, Patsch C, Burcin M, Meyer CA, Westenskow PD, Cowan CA. Roudnicky F, et al. Among authors: sach peltason l. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):19854-19865. doi: 10.1073/pnas.1911532117. Epub 2020 Aug 5. Proc Natl Acad Sci U S A. 2020. PMID: 32759214 Free PMC article.
Multiscale modelling of drug mechanism and safety.
Zhang JD, Sach-Peltason L, Kramer C, Wang K, Ebeling M. Zhang JD, et al. Among authors: sach peltason l. Drug Discov Today. 2020 Mar;25(3):519-534. doi: 10.1016/j.drudis.2019.12.009. Epub 2019 Dec 30. Drug Discov Today. 2020. PMID: 31899257 Free article. Review.
Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment.
Jaklin M, Zhang JD, Schäfer N, Clemann N, Barrow P, Küng E, Sach-Peltason L, McGinnis C, Leist M, Kustermann S. Jaklin M, et al. Among authors: sach peltason l. Toxicol Sci. 2022 Jun 28;188(1):17-33. doi: 10.1093/toxsci/kfac046. Toxicol Sci. 2022. PMID: 35485993 Free PMC article.
Clinical Characterization of Epilepsy in Children With Angelman Syndrome.
Cassater D, Bustamante M, Sach-Peltason L, Rotenberg A, Nespeca M, Tan WH, Bird LM, Hipp JF. Cassater D, et al. Among authors: sach peltason l. Pediatr Neurol. 2021 Nov;124:42-50. doi: 10.1016/j.pediatrneurol.2021.08.007. Epub 2021 Aug 31. Pediatr Neurol. 2021. PMID: 34536900 Free PMC article. Clinical Trial.
Computational Predictions of Nonclinical Pharmacokinetics at the Drug Design Stage.
Stoyanova R, Katzberger PM, Komissarov L, Khadhraoui A, Sach-Peltason L, Groebke Zbinden K, Schindler T, Manevski N. Stoyanova R, et al. Among authors: sach peltason l. J Chem Inf Model. 2023 Jan 23;63(2):442-458. doi: 10.1021/acs.jcim.2c01134. Epub 2023 Jan 3. J Chem Inf Model. 2023. PMID: 36595708
Discovery of a first-in-class orally available HBV cccDNA inhibitor.
Wang L, Zhu Q, Zhang JD, Zhang Y, Ni X, Xiang K, Jiang J, Li B, Yu Y, Hu H, Zhang M, Wu W, Zeng J, Yan Z, Dai J, Sun K, Zhang X, Chen D, Feng S, Sach-Peltason L, Young JAT, Gao L. Wang L, et al. Among authors: sach peltason l. J Hepatol. 2023 Apr;78(4):742-753. doi: 10.1016/j.jhep.2022.12.014. Epub 2022 Dec 30. J Hepatol. 2023. PMID: 36587899