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Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal.
Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N. Svensson MND, et al. Among authors: sacchetti c. Sci Adv. 2020 Jun 26;6(26):eaba4353. doi: 10.1126/sciadv.aba4353. eCollection 2020 Jun. Sci Adv. 2020. PMID: 32637608 Free PMC article.
TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.
Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N. Stanford SM, et al. Among authors: sacchetti c. Ann Rheum Dis. 2016 Jan;75(1):295-302. doi: 10.1136/annrheumdis-2014-205790. Epub 2014 Nov 6. Ann Rheum Dis. 2016. PMID: 25378349 Free PMC article.
Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.
Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. Doody KM, et al. Among authors: sacchetti c. Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616. Sci Transl Med. 2015. PMID: 25995222 Free PMC article.
Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.
Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N. Stanford SM, et al. Among authors: sacchetti c. Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442. Arthritis Rheumatol. 2016. PMID: 26414708 Free PMC article.
Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.
Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. Maeshima K, et al. Among authors: sacchetti c. JCI Insight. 2016 May 19;1(7):e86580. doi: 10.1172/jci.insight.86580. JCI Insight. 2016. PMID: 27275015 Free PMC article.
PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis.
Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N. Sacchetti C, et al. Nat Commun. 2017 Oct 20;8(1):1060. doi: 10.1038/s41467-017-01168-1. Nat Commun. 2017. PMID: 29057934 Free PMC article.
250 results