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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins.
Lu X, Chandravanshi M, Sabbasani VR, Gaikwad S, Hughitt VK, Gyabaah-Kessie N, Scroggins BT, Das S, Myint W, Clapp ME, Schwieters CD, Dyba MA, Bolhuis DL, Koscielniak JW, Andresson T, Emanuele MJ, Brown NG, Matsuo H, Chari R, Citrin DE, Mock BA, Swenson RE, Walters KJ. Lu X, et al. Among authors: sabbasani vr. Nat Commun. 2024 Mar 20;15(1):2485. doi: 10.1038/s41467-024-46644-7. Nat Commun. 2024. PMID: 38509117 Free PMC article.
Structural Relationships to Efficacy for Prazole-Derived Antivirals.
Nyenhuis DA, Watanabe S, Bernstein R, Swenson RE, Raju N, Sabbasani VR, Mushti C, Lee DY, Carter C, Tjandra N. Nyenhuis DA, et al. Among authors: sabbasani vr. Adv Sci (Weinh). 2024 Mar 6:e2308312. doi: 10.1002/advs.202308312. Online ahead of print. Adv Sci (Weinh). 2024. PMID: 38447164
hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50.
Osei-Amponsa V, Chandravanshi M, Lu X, Magidson V, Das S, Andresson T, Dyba M, Sabbasani VR, Swenson RE, Fromont C, Shrestha B, Zhao Y, Clapp ME, Chari R, Walters KJ. Osei-Amponsa V, et al. Among authors: sabbasani vr. Mol Cell. 2024 Feb 1;84(3):522-537.e8. doi: 10.1016/j.molcel.2023.11.035. Epub 2023 Dec 26. Mol Cell. 2024. PMID: 38151017
PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer.
Torres-Ayuso P, Katerji M, Mehlich D, Lookingbill SA, Sabbasani VR, Liou H, Casillas AL, Chauhan SS, Serwa R, Rubin MR, Marusiak AA, Swenson RE, Warfel NA, Brognard J. Torres-Ayuso P, et al. Among authors: sabbasani vr. Cell Chem Biol. 2024 Feb 15;31(2):326-337.e11. doi: 10.1016/j.chembiol.2023.10.023. Epub 2023 Nov 27. Cell Chem Biol. 2024. PMID: 38016478 Free article.
Rapid 13C Hyperpolarization of the TCA Cycle Intermediate α-Ketoglutarate via SABRE-SHEATH.
Adelabu I, Ettedgui J, Joshi SM, Nantogma S, Chowdhury MRH, McBride S, Theis T, Sabbasani VR, Chandrasekhar M, Sail D, Yamamoto K, Swenson RE, Krishna MC, Goodson BM, Chekmenev EY. Adelabu I, et al. Among authors: sabbasani vr. Anal Chem. 2022 Oct 4;94(39):13422-13431. doi: 10.1021/acs.analchem.2c02160. Epub 2022 Sep 22. Anal Chem. 2022. PMID: 36136056 Free PMC article.
Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.
Lu X, Sabbasani VR, Osei-Amponsa V, Evans CN, King JC, Tarasov SG, Dyba M, Das S, Chan KC, Schwieters CD, Choudhari S, Fromont C, Zhao Y, Tran B, Chen X, Matsuo H, Andresson T, Chari R, Swenson RE, Tarasova NI, Walters KJ. Lu X, et al. Among authors: sabbasani vr. Nat Commun. 2021 Dec 16;12(1):7318. doi: 10.1038/s41467-021-27570-4. Nat Commun. 2021. PMID: 34916494 Free PMC article.
Bifunctional small molecules that mediate the degradation of extracellular proteins.
Caianiello DF, Zhang M, Ray JD, Howell RA, Swartzel JC, Branham EMJ, Chirkin E, Sabbasani VR, Gong AZ, McDonald DM, Muthusamy V, Spiegel DA. Caianiello DF, et al. Among authors: sabbasani vr. Nat Chem Biol. 2021 Sep;17(9):947-953. doi: 10.1038/s41589-021-00851-1. Epub 2021 Aug 19. Nat Chem Biol. 2021. PMID: 34413525
17 results