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Blockade of the protease ADAM17 ameliorates experimental pancreatitis.
Saad MI, Weng T, Lundy J, Gearing LJ, West AC, Harpur CM, Alanazi M, Hodges C, Croagh D, Kumar B, Sagi I, Rose-John S, Jenkins BJ. Saad MI, et al. Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2213744119. doi: 10.1073/pnas.2213744119. Epub 2022 Oct 10. Proc Natl Acad Sci U S A. 2022. PMID: 36215509 Free PMC article.
ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.
Saad MI, Alhayyani S, McLeod L, Yu L, Alanazi M, Deswaerte V, Tang K, Jarde T, Smith JA, Prodanovic Z, Tate MD, Balic JJ, Watkins DN, Cain JE, Bozinovski S, Algar E, Kohmoto T, Ebi H, Ferlin W, Garbers C, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ. Saad MI, et al. EMBO Mol Med. 2019 Apr;11(4):e9976. doi: 10.15252/emmm.201809976. EMBO Mol Med. 2019. PMID: 30833304 Free PMC article.
Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease.
Balic JJ, Saad MI, Dawson R, West AJ, McLeod L, West AC, D'Costa K, Deswaerte V, Dev A, Sievert W, Gough DJ, Bhathal PS, Ferrero RL, Jenkins BJ. Balic JJ, et al. Among authors: saad mi. Am J Pathol. 2020 Jun;190(6):1256-1270. doi: 10.1016/j.ajpath.2020.01.021. Epub 2020 Mar 19. Am J Pathol. 2020. PMID: 32201262 Free article.
ADAM17 Deficiency Protects against Pulmonary Emphysema.
Saad MI, McLeod L, Hodges C, Vlahos R, Rose-John S, Ruwanpura S, Jenkins BJ. Saad MI, et al. Am J Respir Cell Mol Biol. 2021 Feb;64(2):183-195. doi: 10.1165/rcmb.2020-0214OC. Am J Respir Cell Mol Biol. 2021. PMID: 33181031
IL-6 family cytokines in respiratory health and disease.
Dawson RE, Jenkins BJ, Saad MI. Dawson RE, et al. Among authors: saad mi. Cytokine. 2021 Jul;143:155520. doi: 10.1016/j.cyto.2021.155520. Epub 2021 Apr 16. Cytokine. 2021. PMID: 33875334 Review.
35 results