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HBK-15, a Multimodal Compound, Showed an Anxiolytic-Like Effect in Rats.
Lustyk K, Sałaciak K, Jakubczyk M, Jastrzębska-Więsek M, Partyka A, Wesołowska A, Marona H, Pytka K. Lustyk K, et al. Among authors: salaciak k. Neurochem Res. 2023 Mar;48(3):839-845. doi: 10.1007/s11064-022-03802-x. Epub 2022 Nov 9. Neurochem Res. 2023. PMID: 36350432 Free PMC article.
HBK-17, a 5-HT1A Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling.
Pytka K, Głuch-Lutwin M, Żmudzka E, Sałaciak K, Siwek A, Niemczyk K, Walczak M, Smolik M, Olczyk A, Gałuszka A, Śmieja J, Filipek B, Sapa J, Kołaczkowski M, Pańczyk K, Waszkielewicz A, Marona H. Pytka K, et al. Among authors: salaciak k. Front Pharmacol. 2018 Oct 16;9:1146. doi: 10.3389/fphar.2018.01146. eCollection 2018. Front Pharmacol. 2018. PMID: 30410441 Free PMC article.
The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling.
Sałaciak K, Głuch-Lutwin M, Siwek A, Szafarz M, Kazek G, Bednarski M, Nowiński L, Mitchell E, Jastrzębska-Więsek M, Partyka A, Wesołowska A, Kołaczkowski M, Szkaradek N, Marona H, Sapa J, Pytka K. Sałaciak K, et al. J Psychopharmacol. 2020 Dec;34(12):1431-1442. doi: 10.1177/0269881120959605. Epub 2020 Oct 24. J Psychopharmacol. 2020. PMID: 33103555
The selective 5-HT1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress.
Głuch-Lutwin M, Sałaciak K, Gawalska A, Jamrozik M, Sniecikowska J, Newman-Tancredi A, Kołaczkowski M, Pytka K. Głuch-Lutwin M, et al. Among authors: salaciak k. Psychopharmacology (Berl). 2021 Aug;238(8):2249-2260. doi: 10.1007/s00213-021-05849-0. Epub 2021 May 10. Psychopharmacology (Berl). 2021. PMID: 33973045 Free PMC article.
16 results